CMAUP Plant Collective Molecular Activities

Plant Name: Citrus hystrix

Taxonomic Information:

Plant ID: NPO30686
Plant Latin Name: Citrus hystrix
Taxonomy Genus: Citrus
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 771927-1

Used in Medicines:

Country/Region:

Thailand; Indonesia; India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

Australia; Bangladesh; Myanmar; Philippines; Indonesia; India; New Caledonia; Cambodia; Trinidad and Tobago; Vietnam; China; Papua New Guinea; Sri Lanka; Thailand; Fiji

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALOX15; ALDH1A1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4; CYP2C19; CYP2C9; CYP2B6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2B6	Cytochrome P450 2B6	P20813	CHEMBL4729
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.810E-13	3.942E-09	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.931E-13	7.547E-09	CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.039E-12	2.206E-08	CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.968E-12	2.947E-08	CYP2B6, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.120E-12	2.947E-08	ALOX15, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.619E-10	6.062E-07	CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	6.510E-10	9.451E-07	CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.024E-08	9.695E-06	CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.782E-08	1.552E-05	CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	3.162E-08	2.459E-05	CYP2B6, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	6.180E-08	4.486E-05	CYP2B6, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1.207E-07	8.478E-05	CYP2B6, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.502E-07	2.971E-04	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.002E-07	5.298E-04	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.743E-06	3.581E-03	CYP2C19, CYP2C9
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.210E-05	6.129E-03	CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009056; catabolic process	1.736E-05	8.217E-03	ALDH1A1, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.667E-04	7.261E-02	CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, LMNA
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	2.944E-02	1.000E+00	ALOX15

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.342E-11	3.514E-10	CYP2C9, CYP2B6, CYP2D6, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.485E-10	1.863E-09	CYP2C9, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.805E-09	2.641E-08	CYP2C9, CYP2B6, ALOX15, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.042E-09	2.641E-08	CYP2C9, CYP2B6, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.131E-08	3.392E-08	CYP2C9, CYP2B6, CYP2D6, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.411E-08	1.603E-07	CYP2C9, CYP2D6, ALOX15, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.404E-06	3.008E-06	CYP2C9, CYP2B6, ALOX15, ALDH1A1, CYP2C19, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.665E-06	6.872E-06	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.826E-02	3.043E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.297E-02	3.445E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases