CMAUP Plant Collective Molecular Activities

Plant Name: Gnaphalium affine

Taxonomic Information:

Plant ID: NPO30669
Plant Latin Name: Gnaphalium affine
Taxonomy Genus: Gnaphalium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antiperiodic; Antitussive; Expectorant; Febrifuge

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HCAR2;
Hydrolase	GAA;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group A	THRB;
Enzyme_unclassified	ALDH1A1;
ATP-binding cassette	ABCG2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032502; developmental process	GO:0009887; animal organ morphogenesis	2.322E-04	8.114E-01	GAA, MAPK1, THRB
BP	GO:0007610; behavior	GO:0007610; behavior	4.080E-04	8.114E-01	GAA, MAPK1, THRB
BP	GO:0008152; metabolic process	GO:0016052; carbohydrate catabolic process	4.923E-04	8.114E-01	ALDH1A1, GAA
MF	GO:0003824; catalytic activity	GO:0004574; oligo-1,6-glucosidase activity	6.212E-04	8.114E-01	GAA
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	9.316E-04	8.114E-01	GAA
MF	GO:0005488; binding	GO:0005497; androgen binding	1.242E-03	8.667E-01	ALDH1A1
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	1.242E-03	8.667E-01	GAA
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.173E-03	8.943E-01	ALDH1A1
MF	GO:0005215; transporter activity	GO:0008559; xenobiotic transmembrane transporting ATPase activity	2.173E-03	8.943E-01	ABCG2
CC	GO:0016020; membrane	GO:0005886; plasma membrane	2.709E-02	1.000E+00	ABCG2, GAA, HCAR2, MAPK1
CC	GO:0016020; membrane	GO:0044853; plasma membrane raft	2.794E-02	1.000E+00	MAPK1
CC	GO:0044464; cell part	GO:0035578; azurophil granule lumen	2.794E-02	1.000E+00	MAPK1
CC	GO:0044464; cell part	GO:0043204; perikaryon	3.520E-02	1.000E+00	MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	5.098E-04	4.792E-02	THRB, MAPK1
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1.164E-02	5.338E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.224E-02	5.338E-02	MAPK1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.967E-03	5.338E-02	GAA
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	1.668E-02	5.338E-02	MAPK1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	1.432E-02	5.338E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	1.550E-02	5.338E-02	MAPK1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.668E-02	5.338E-02	GAA
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.698E-02	5.338E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	1.787E-02	5.338E-02	MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB; HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases