CMAUP Plant Collective Molecular Activities

Plant Name: Gnaphalium affine

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB; HCAR2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases