CMAUP Plant Collective Molecular Activities

Plant Name: Derris indica

Taxonomic Information:

Plant ID: NPO3037
Plant Latin Name: Derris indica
Taxonomy Genus: Derris
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Ayurveda; Siddha

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
ATP-binding cassette	ABCG2;
Unclassified	MAPT; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2D6; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.052E-14	1.971E-09	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.789E-10	3.036E-06	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	8.948E-10	6.494E-06	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	6.403E-09	2.451E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	6.403E-09	2.451E-05	CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	6.754E-09	2.451E-05	CYP2C19, CYP2C9, CYP2D6, CYP3A4, NPC1
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.973E-08	8.651E-05	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	6.340E-08	1.151E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1.370E-07	2.131E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.557E-07	2.260E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	3.377E-07	4.595E-04	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.752E-07	8.168E-04	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.059E-06	4.213E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006082; organic acid metabolic process	6.038E-06	4.696E-03	ABCG2, CYP2C19, CYP2C9, CYP2D6, NPC1
BP	GO:0008152; metabolic process	GO:0032787; monocarboxylic acid metabolic process	1.232E-05	9.240E-03	CYP2C19, CYP2C9, CYP2D6, NPC1
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.736E-05	2.578E-02	ABCG2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, NPC1
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.601E-04	6.972E-02	CYP2C19, CYP2C9, CYP2D6, CYP3A4
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	1.759E-03	4.286E-01	ABCG2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, MAPT, NPC1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.505E-09	6.757E-08	CYP2C9, CYP2D6, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.556E-08	7.167E-07	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.616E-06	8.079E-06	CYP2C9, CYP2D6, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.887E-06	1.766E-05	CYP2C9, CYP2D6, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.298E-06	8.616E-06	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.966E-04	4.631E-04	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.161E-04	4.631E-04	CYP2C9, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.580E-04	4.837E-04	CYP3A4, ABCG2
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.873E-03	1.146E-02	CYP2C9, CYP2C19, CYP3A4
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.530E-02	2.181E-02	ABCG2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases