CMAUP Plant Collective Molecular Activities

Plant Name: Cassia mimosoides

Taxonomic Information:

Plant ID: NPO29780
Plant Latin Name: Cassia mimosoides
Taxonomy Genus: Cassia
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; RECQL;
Protein Kinase	MAPK1;
Transcription Factor	NFKB1;
Unclassified	MAPT; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.745E-09	5.978E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.014E-08	3.282E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.143E-07	5.910E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.768E-06	6.983E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.924E-06	6.983E-03	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.323E-05	3.602E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.940E-05	3.840E-02	CYP2C9, CYP3A4
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.940E-05	3.840E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.292E-05	4.159E-02	SMN1, SMN2
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.192E-05	4.458E-02	CYP2C19, CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0043204; perikaryon	3.276E-05	4.458E-02	MAPK1, SMN1, SMN2
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	3.991E-05	4.678E-02	CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	4.511E-05	4.678E-02	CYP2C19, CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	4.489E-05	4.678E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.487E-07	5.295E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.357E-06	3.751E-04	CYP2C9, CYP3A4, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.730E-05	8.054E-04	CYP2C9, MAPK1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.070E-05	4.210E-04	CYP2C9, CYP3A4, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.133E-04	5.182E-03	MAPK1, MAPT, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	4.317E-04	5.182E-03	MAPK1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.108E-04	5.182E-03	CYP2C9, CYP2C19
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	4.317E-04	5.182E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	5.787E-04	5.182E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	6.883E-04	5.182E-03	MAPK1, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.613E-04	5.182E-03	CYP2C9, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	7.075E-04	5.182E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	7.075E-04	5.182E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	5.613E-04	5.182E-03	MAPK1, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.075E-04	5.182E-03	CYP2C9, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	7.075E-04	5.182E-03	MAPK1, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.348E-03	7.294E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.049E-03	6.516E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	7.466E-04	5.182E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.402E-03	7.294E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	9.802E-04	6.425E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	1.429E-03	7.294E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	1.483E-03	7.294E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	1.429E-03	7.294E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.596E-03	7.534E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.833E-03	7.987E-03	MAPK1, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.895E-03	7.987E-03	MAPK1, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.567E-03	9.772E-03	MAPK1, NFKB1
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	2.287E-03	9.129E-03	MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.895E-03	7.987E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.321E-03	9.129E-03	MAPK1, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases