CMAUP Plant Collective Molecular Activities

Plant Name: Cassia mimosoides

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.745E-09	5.978E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.014E-08	3.282E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.143E-07	5.910E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.768E-06	6.983E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.924E-06	6.983E-03	CYP2C19, CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	4.487E-07	5.295E-05	CYP2C9; CYP3A4; CYP2C19
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	6.357E-06	3.751E-04	CYP2C9; CYP3A4; CYP2C19
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	2.730E-05	8.054E-04	CYP2C9; MAPK1; CYP2C19
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.070E-05	4.210E-04	CYP2C9; CYP3A4; CYP2C19
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	3.133E-04	5.182E-03	MAPK1; MAPT; NFKB1
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	4.317E-04	5.182E-03	MAPK1; NFKB1
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	5.108E-04	5.182E-03	CYP2C9; CYP2C19
hsa04621	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	4.317E-04	5.182E-03	MAPK1; NFKB1
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	5.787E-04	5.182E-03	MAPK1; NFKB1
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	6.883E-04	5.182E-03	MAPK1; NFKB1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	5.613E-04	5.182E-03	CYP2C9; CYP3A4
hsa05220	Chronic myeloid leukemia_Homo sapiens_hsa05220	7.075E-04	5.182E-03	MAPK1; NFKB1
hsa04662	B cell receptor signaling pathway_Homo sapiens_hsa04662	7.075E-04	5.182E-03	MAPK1; NFKB1
hsa05131	Shigellosis_Homo sapiens_hsa05131	5.613E-04	5.182E-03	MAPK1; NFKB1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	7.075E-04	5.182E-03	CYP2C9; CYP3A4
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	7.075E-04	5.182E-03	MAPK1; NFKB1
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.348E-03	7.294E-03	MAPK1; NFKB1
hsa05215	Prostate cancer_Homo sapiens_hsa05215	1.049E-03	6.516E-03	MAPK1; NFKB1
hsa05133	Pertussis_Homo sapiens_hsa05133	7.466E-04	5.182E-03	MAPK1; NFKB1
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.402E-03	7.294E-03	MAPK1; NFKB1
hsa05132	Salmonella infection_Homo sapiens_hsa05132	9.802E-04	6.425E-03	MAPK1; NFKB1
hsa04660	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.429E-03	7.294E-03	MAPK1; NFKB1
hsa04620	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.483E-03	7.294E-03	MAPK1; NFKB1
hsa05142	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.429E-03	7.294E-03	MAPK1; NFKB1
hsa04668	TNF signaling pathway_Homo sapiens_hsa04668	1.596E-03	7.534E-03	MAPK1; NFKB1
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	1.833E-03	7.987E-03	MAPK1; NFKB1
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.895E-03	7.987E-03	MAPK1; NFKB1
hsa04210	Apoptosis_Homo sapiens_hsa04210	2.567E-03	9.772E-03	MAPK1; NFKB1
hsa04380	Osteoclast differentiation_Homo sapiens_hsa04380	2.287E-03	9.129E-03	MAPK1; NFKB1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.895E-03	7.987E-03	MAPK1; NFKB1
hsa05161	Hepatitis B_Homo sapiens_hsa05161	2.788E-03	1.028E-02	MAPK1; NFKB1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	2.321E-03	9.129E-03	MAPK1; NFKB1
hsa05164	Influenza A_Homo sapiens_hsa05164	3.975E-03	1.340E-02	MAPK1; NFKB1
hsa03013	RNA transport_Homo sapiens_hsa03013	3.843E-03	1.334E-02	SMN2; SMN1
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	3.670E-03	1.312E-02	MAPK1; MAPT
hsa04062	Chemokine signaling pathway_Homo sapiens_hsa04062	4.524E-03	1.443E-02	MAPK1; NFKB1
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	5.411E-03	1.637E-02	MAPK1; NFKB1
hsa05152	Tuberculosis_Homo sapiens_hsa05152	4.109E-03	1.347E-02	MAPK1; NFKB1
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	5.107E-03	1.586E-02	MAPK1; NFKB1
hsa04014	Ras signaling pathway_Homo sapiens_hsa04014	6.594E-03	1.945E-02	MAPK1; NFKB1
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.440E-02	4.046E-02	MAPK1; NFKB1
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	1.106E-02	3.184E-02	MAPK1; NFKB1
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	1.920E-02	4.926E-02	MAPK1; NFKB1
hsa05020	Prion diseases_Homo sapiens_hsa05020	1.909E-02	4.926E-02	MAPK1
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	1.584E-02	4.248E-02	MAPK1
hsa04320	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.475E-02	4.049E-02	MAPK1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; NFKB1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases