CMAUP Plant Collective Molecular Activities

Plant Name: Papaver bracteatum

Taxonomic Information:

Plant ID: NPO29391
Plant Latin Name: Papaver bracteatum
Taxonomy Genus: Papaver
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 215227
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nicotinic acetylcholine receptor	CHRNA4; CHRNA3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nicotinic acetylcholine receptor	CHRNA4	Neuronal acetylcholine receptor protein alpha-4 subunit	P43681	CHEMBL1882
Nicotinic acetylcholine receptor	CHRNA3	Neuronal acetylcholine receptor subunit alpha-3	P32297	CHEMBL3068
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0007610; behavior	GO:0035095; behavioral response to nicotine	3.377E-07	7.353E-03	CHRNA3, CHRNA4
MF	GO:0060089; molecular transducer activity	GO:0015464; acetylcholine receptor activity	2.459E-06	8.549E-03	CHRNA3, CHRNA4
BP	GO:0050896; response to stimulus	GO:0095500; acetylcholine receptor signaling pathway	4.066E-06	8.853E-03	CHRNA3, CHRNA4
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	5.640E-06	9.447E-03	CHRNA3, CHRNA4
BP	GO:0023052; signaling	GO:0007267; cell-cell signaling	3.404E-05	4.118E-02	CHRNA3, CHRNA4, TSHR
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	3.764E-05	4.282E-02	CHRNA3, CHRNA4
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	3.537E-04	1.831E-01	CHRNA3, CHRNA4
CC	GO:0044464; cell part	GO:0030425; dendrite	8.841E-04	2.917E-01	CHRNA3, CHRNA4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.628E-06	1.840E-05	CHRNA3, CHRNA4, TSHR
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	9.125E-05	3.194E-04	CHRNA3, CHRNA4
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	5.988E-03	1.173E-02	CHRNA4
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	7.929E-03	1.173E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8.377E-03	1.173E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.061E-02	1.238E-02	TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.956E-02	2.956E-02	TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases