CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Smoking cessation	F17.2	CHRNA4
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRNA4
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRNA4
NA: NA	Anxiety disorders	NA	CHRNA4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRNA4
I00-I99: Diseases of the circulatory system	Hypotension	I95	CHRNA4
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
NA: NA	Hypertensive emergencies	NA	CHRNA4
NA: NA	Aneurysm	NA	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRNA4; CHRNA4
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRNA4; CHRNA4
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	CHRNA4
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Tobacco dependence	F17	CHRNA4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	CHRNA4; CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Papaver bracteatum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases