CMAUP Plant Collective Molecular Activities

Plant Name: Amomum compactum

Taxonomic Information:

Plant ID: NPO29010
Plant Latin Name: Amomum compactum
Taxonomy Genus: Amomum
Taxonomy Family: Zingiberaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 795489-1

Used in Medicines:

Country/Region:

Indonesia

Traditional Medicine System:

Geographical Distribution:

India; Indonesia; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Transient receptor potential channel	TRPA1;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group A	THRB;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0050877; nervous system process	6.372E-05	5.637E-01	MAPK1, MAPT, THRB, TRPA1
BP	GO:0032501; multicellular organismal process	GO:0019233; sensory perception of pain	1.100E-04	5.637E-01	MAPK1, TRPA1
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	2.389E-04	5.637E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.762E-04	5.637E-01	MAPK1, MAPT
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	6.212E-04	5.881E-01	TSHR
CC	GO:0043226; organelle	GO:0016604; nuclear body	9.251E-04	5.967E-01	LMNA, MAPT, THRB
MF	Unclassified;	GO:0004871; signal transducer activity	8.023E-04	5.967E-01	MAPK1, THRB, TRPA1, TSHR
MF	GO:0005488; binding	GO:0019902; phosphatase binding	1.051E-03	6.538E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	1.552E-03	7.192E-01	TRPA1
MF	GO:0005488; binding	GO:0070324; thyroid hormone binding	2.173E-03	7.263E-01	THRB
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	2.173E-03	7.263E-01	THRB
CC	GO:0044464; cell part	GO:0030424; axon	2.553E-03	7.316E-01	MAPK1, MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	3.412E-03	7.905E-01	MAPT
MF	Unclassified;	GO:0004707; MAP kinase activity	4.341E-03	8.537E-01	MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	5.098E-04	3.224E-02	THRB, MAPK1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.165E-04	3.224E-02	LMNA, MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.029E-03	3.224E-02	MAPK1, MAPT
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.439E-03	3.382E-02	MAPK1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.348E-03	4.330E-02	MAPK1, MAPT
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.764E-03	4.330E-02	THRB, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	3.489E-02	4.951E-02	MAPK1
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	3.605E-02	4.951E-02	MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	3.547E-02	4.951E-02	MAPK1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	3.634E-02	4.951E-02	MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases