CMAUP Plant Collective Molecular Activities

Plant Name: Sapium haematospermum

Taxonomic Information:

Plant ID: NPO28952
Plant Latin Name: Sapium haematospermum
Taxonomy Genus: Sapium
Taxonomy Family: Euphorbiaceae

Plant External Links:

NCBI TaxonomyDB: 316852
Plant-of-the-World-Online: 355819-1

Used in Medicines:

Country/Region:

Argentina

Traditional Medicine System:

Geographical Distribution:

Brazil; Paraguay; Argentina; Bolivia; Uruguay

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; BLM; TNKS; TNKS2;
Lyase	CA2; CA7; CA4; CA12;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.930E-11	1.073E-06	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.116E-09	2.304E-05	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.868E-09	3.533E-05	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.235E-07	2.251E-03	CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	9.914E-07	2.699E-03	BLM, CA12, CA2, CA4, CA7, TNKS
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	1.447E-06	3.150E-03	TNKS, TNKS2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.476E-11	1.495E-09	CA12, CA2, CA4, CA7
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.661E-05	5.661E-04	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases