CMAUP Plant Collective Molecular Activities

Plant Name: Garcinia lucida

Taxonomic Information:

Plant ID: NPO2842
Plant Latin Name: Garcinia lucida
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae

Plant External Links:

NCBI TaxonomyDB: 469933
Plant-of-the-World-Online: 428059-1

Used in Medicines:

Country/Region:

Cameroon

Traditional Medicine System:

Geographical Distribution:

Gabon; Congo; Cameroon

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; CBR1; APEX1;
Nicotinic acetylcholine receptor	CHRNA3; CHRNA4;
Oxidoreductase	ALOX5;
Serine protease	DPP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Nicotinic acetylcholine receptor	CHRNA3	Neuronal acetylcholine receptor subunit alpha-3	P32297	CHEMBL3068
Nicotinic acetylcholine receptor	CHRNA4	Neuronal acetylcholine receptor protein alpha-4 subunit	P43681	CHEMBL1882
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Serine protease	DPP4	Dipeptidyl peptidase IV	P27487	CHEMBL284

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0007610; behavior	GO:0035095; behavioral response to nicotine	2.362E-06	5.143E-02	CHRNA3, CHRNA4
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	2.665E-05	5.618E-02	CHRNA3, CHRNA4, DPP4
BP	GO:0050896; response to stimulus	GO:0095500; acetylcholine receptor signaling pathway	2.838E-05	5.618E-02	CHRNA3, CHRNA4
MF	GO:0060089; molecular transducer activity	GO:0015464; acetylcholine receptor activity	1.718E-05	5.618E-02	CHRNA3, CHRNA4
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	3.934E-05	6.119E-02	CHRNA3, CHRNA4
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.611E-04	2.630E-01	CHRNA3, CHRNA4
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	2.406E-03	7.175E-01	CHRNA3, CHRNA4
CC	GO:0044464; cell part	GO:0005641; nuclear envelope lumen	2.896E-03	7.507E-01	ALOX5
CC	GO:0016020; membrane	GO:0098857; membrane microdomain	4.640E-03	9.262E-01	CHRNA3, DPP4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.966E-04	2.359E-03	CBR1, ALOX5
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	6.295E-04	3.777E-03	CHRNA3, CHRNA4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.834E-03	1.533E-02	CHRNA3, CHRNA4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.737E-02	3.474E-02	ALOX5
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	1.392E-02	3.340E-02	CHRNA4
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.149E-02	3.340E-02	APEX1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.528E-02	4.144E-02	CBR1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	4.058E-02	4.427E-02	ALOX5
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.835E-02	4.144E-02	CBR1
09150 Organismal Systems	09154 Digestive system	hsa04974	Protein digestion and absorption	3.108E-02	4.144E-02	DPP4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases