CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRNA4; CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Smoking cessation	F17.2	CHRNA4
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRNA4; CHRNA4
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Hypoglycemia	E16.0-E16.2	DPP4
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Bone marrow transplantation	D89.8, T86	DPP4
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRNA4
NA: NA	Anxiety disorders	NA	CHRNA4
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5
C00-D49: Neoplasms	Ocular cancer	C69	APEX1
NA: NA	Aneurysm	NA	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRNA4
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRNA4
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DPP4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Tobacco dependence	F17	CHRNA4
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRNA4
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	DPP4
I00-I99: Diseases of the circulatory system	Hypotension	I95	CHRNA4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	DPP4
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Autism	F84.0	DPP4
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	DPP4
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	CHRNA4; CHRNA4
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	DPP4
C00-D49: Neoplasms	Hematological malignancies	C81-C86	DPP4
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRNA4
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
NA: NA	Hypertensive emergencies	NA	CHRNA4
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5; ALOX5; CBR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Garcinia lucida

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases