CMAUP Plant Collective Molecular Activities

Plant Name: Corydalis pallida

Taxonomic Information:

Plant ID: NPO28372
Plant Latin Name: Corydalis pallida
Taxonomy Genus: Corydalis
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 38903
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	DRD1;
Lyase	CA2; CA3; CA14; CA7; CA5A; CA6; CA12; CA9; CA1;
Transcription Factor	NFKB1;
Unclassified	LMNA; F3; SIGMAR1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.650E-07	2.994E-04	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.179E-25	2.567E-21	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.186E-06	3.087E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.652E-20	1.799E-16	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.515E-18	8.248E-15	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.091E-05	1.188E-02	CYP2C19, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	1.188E-02	CA1, CA2
MF	GO:0005488; binding	GO:0043169; cation binding	2.323E-05	2.409E-02	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9, CYP2C19, CYP2D6, DRD1
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	3.267E-05	3.234E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.184E-25	3.347E-23	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	5.953E-04	2.083E-02	DRD1, NFKB1, TSHR
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	7.811E-04	2.083E-02	DRD1, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.543E-03	3.086E-02	CYP2D6, CYP2C19
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3.268E-03	5.230E-02	F3, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.001E-03	5.335E-02	CYP2D6, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.176E-03	7.058E-02	LMNA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	5.789E-02	1.326E-01	NFKB1
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	5.789E-02	1.326E-01	NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	6.029E-02	1.326E-01	NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases