CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.650E-07	2.994E-04	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.179E-25	2.567E-21	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.186E-06	3.087E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.652E-20	1.799E-16	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.515E-18	8.248E-15	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	4.184E-25	3.347E-23	CA12; CA1; CA3; CA2; CA5A; CA7; CA6; CA9; CA14
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	5.953E-04	2.083E-02	DRD1; NFKB1; TSHR
hsa05030	Cocaine addiction_Homo sapiens_hsa05030	7.811E-04	2.083E-02	DRD1; NFKB1
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.543E-03	3.086E-02	CYP2D6; CYP2C19

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3
C00-D49: Neoplasms	Cancer	C00-C96	CA9; CA1; NFKB1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
C00-D49: Neoplasms	Breast cancer	C50	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; DRD1
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
NA: NA	Edema	NA	CA2
C00-D49: Neoplasms	Renal cancer	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2; CYP2D6
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1
C00-D49: Neoplasms	Pancreatic cancer	C25	F3
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Corydalis pallida

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases