CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; PKM; IDO1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; APEX1; POLB;
Protein Phosphatase	CDC25B;
Protein Kinase	MAPK1; CDK8;
Lyase	CA2; CA12; CA9; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR;
Cysteine protease	CASP7;
Transcription Factor	AHR; HIF1A; TP53;
Unclassified	LMNA; FABP3; FABP5; FABP4;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789

Showing 1 to 10 of 38 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.651E-09	6.413E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	7.977E-09	1.323E-05	ALDH1A1, ALOX15, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B10, HSD17B2, IDO1, PKM, TYR
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.084E-09	1.323E-05	CA12, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.302E-08	2.783E-05	CA12, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.438E-08	5.785E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	8.822E-08	6.547E-05	CA2, CA9, CYP1A1, CYP1A2, FABP3, FFAR1, HSD17B2, IDO1, NR1H4, TP53, TYR
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	9.741E-07	4.242E-04	APEX1, CA2, CA9, CASP7, CYP1A1, CYP1A2, CYP1B1, MAPK1, TP53, TYR
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	3.769E-06	1.243E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	7.017E-06	2.050E-03	ACHE, ALDH1A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, IDO1, PKM
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	9.116E-06	2.578E-03	CYP1A1, POLB, TP53

Showing 1 to 10 of 29 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.146E-10	1.605E-08	CA12, CA2, CA4, CA7, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.022E-08	5.615E-06	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.638E-07	4.498E-05	CYP1A2, CYP1A1, CYP1B1, IDO1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.235E-05	3.476E-04	CYP1A2, ALOX15, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.548E-04	3.243E-03	CYP1A2, ALDH1A1, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.591E-04	4.189E-03	CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.411E-04	1.976E-03	CASP7, LMNA, MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.396E-06	8.386E-05	HSD17B2, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	8.764E-06	2.045E-04	FABP3, FABP4, FABP5, PPARA
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	8.672E-04	8.672E-03	CA2, CA4

Showing 1 to 10 of 14 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; MAPK1; PKM; TP53; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	IDO1; ACHE; HIF1A; MAPK1; TP53; CDC25B; CA9;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1; CA9;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;

Showing 1 to 10 of 64 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Foeniculum vulgare

Taxonomic Information:

Plant External Links:

Used in Medicines:

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Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities