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Plant Name: Foeniculum vulgare




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
FFAR1; FFAR4; ADRA2C; ADRA2A; GPBAR1; HCAR2;
Peptide receptor (family A GPCR)
TSHR; NMUR2;
Enzyme_unclassified
ALPI; PLA2G1B; TDP1; BLM; FAAH; RECQL; CTDSP1; TERT; PKM; HPGD; HSD17B1; AKR1B1; HSD17B10; IDO1; ALOX15; ALDH1A1; HSD17B2; AKR1B10; NOX4; BRCA1; APEX1; POLB;
Protein Phosphatase
PTPN1; CDC25B; PTPN2;
Hydrolase
ACHE; GAA;
Transient receptor potential channel
TRPA1;
Protein Kinase
CDK8; DAPK1; FLT3; CDK9; MAPK1;
Lyase
CA3; CA14; CA5B; CA6; CA1; CA9; CA7; CA4; CA2; CA12; CA5A;
Nuclear hormone receptor subfamily 3 group C
AR;
Nuclear hormone receptor subfamily 1 group H
NR1H4;
Nuclear hormone receptor subfamily 3 group B
ESRRA;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARG; PPARD;
Lysine demethylase
KDM4E;
Oxidoreductase
ALOX5; PTGS1; TYR; XDH;
Cysteine protease
CASP7; CASP1;
Metallo protease
MMP1;
Toll-like and Il-1 receptors
TLR2;
Transcription Factor
AHR; HIF1A; TP53;
ATP-binding cassette
ABCC1; ABCG2;
Unclassified
LMNA; FABP5; FABP2; FABP4; MCL1; MAPT; FABP3; RAB9A; NPC1; TTR;
Methyl-lysine/arginine binding protein
L3MBTL1; SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP3A4; CYP2A6; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cysteine protease CASP7 Caspase-7 P55210 CHEMBL3468
Cysteine protease CASP1 Caspase-1 P29466 CHEMBL4801
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Showing 1 to 10 of 92 entries
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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO TypeGO CategoryEnriched GO Termsp-ValueAdjusted p-ValueEnriched Genes
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 5.415E-10 2.144E-07 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C9
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 5.738E-10 2.231E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.790E-09 6.388E-07 CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 7.497E-09 2.163E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0009987; cellular process GO:0071407; cellular response to organic cyclic compound 1.196E-07 2.578E-05 APEX1, AR, BLM, BRCA1, CASP7, CYP1A1, CYP1B1, FLT3, MAPK1, NOX4, NPC1, PPARG
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 3.572E-07 7.007E-05 ABCC1, ALOX15, ALOX5, PLA2G1B, TLR2
BP GO:0050896; response to stimulus GO:0009636; response to toxic substance 5.112E-07 9.355E-05 AHR, AKR1B1, APEX1, CA3, CYP1A1, CYP1B1, HPGD, MAPK1, POLB, TLR2, TP53, TRPA1
BP GO:0008152; metabolic process GO:0006367; transcription initiation from RNA polymerase II promoter 1.043E-06 1.774E-04 AR, CDK8, CDK9, ESRRA, NR1H4, PPARA, PPARD, PPARG
BP GO:0050896; response to stimulus GO:0050728; negative regulation of inflammatory response 1.370E-06 2.211E-04 CYP19A1, FFAR4, NR1H4, PPARA, PPARD, PPARG, PTPN2
BP GO:0009987; cellular process GO:0030522; intracellular receptor signaling pathway 2.045E-06 3.009E-04 AHR, AR, BRCA1, ESRRA, NR1H4, PPARA, PPARD, PPARG
Showing 1 to 10 of 73 entries
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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway IDPathway Namep-ValueAdjusted p-ValueEnriched Genes
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 3.608E-04 3.049E-03 AKR1B10; GAA; AKR1B1
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 9.264E-09 3.131E-07 HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 9.668E-07 1.634E-05 CYP2A6; CYP1A2; XDH
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 3.522E-05 3.968E-04 CYP1A2; CYP1A1; CYP1B1; IDO1
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 4.280E-07 9.042E-06 CYP2C9; PLA2G1B; ALOX5; ALOX15; CYP2C19; PTGS1
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 3.741E-09 2.107E-07 CYP2C9; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 5.687E-07 1.068E-05 CYP2C9; CYP2A6; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 1.442E-22 2.436E-20 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 1.138E-06 1.748E-05 CYP2C9; CYP2A6; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 1.733E-05 2.092E-04 CYP2C9; CYP2A6; CYP1A2; CYP3A4; CYP2C19
Showing 1 to 10 of 31 entries
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Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease CategoryDisease NameICD10 CodeLinked Targets
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5; RAB9A
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
C00-D49: Neoplasms Solid tumours C00-D48 TLR2; PKM; FLT3; CA9; HIF1A; MAPK1; TP53
Showing 1 to 10 of 194 entries
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Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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