CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; PTPRF; ACP1;
Enzyme_unclassified	RECQL; AKR1B10; HSD11B1;
Protein Kinase	PRKCA;
Lyase	CA1; CA5A; CA6; CA12; CA5B;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP2; MMP12;
Unclassified	HTT; LMNA;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.353E-10	1.825E-06	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.605E-10	4.183E-06	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.375E-06	6.856E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	3.634E-06	6.856E-03	ACP1, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	6.746E-06	1.049E-02	PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.710E-12	5.900E-08	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.914E-12	6.438E-08	CA1, CA12, CA5A, CA5B, CA6, L3MBTL1, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.375E-06	6.856E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	3.140E-05	3.256E-02	ACP1, PTPN2

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.687E-12	3.890E-10	CA12, CA1, CA5B, CA5A, CA6
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.308E-02	1.523E-01	AKR1B10
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	6.164E-05	2.558E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	4.065E-03	9.318E-02	MMP2, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	6.736E-03	9.318E-02	MMP2, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	9.236E-03	1.095E-01	PTPN1, PTPRF
09150 Organismal Systems	09155 Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4.823E-02	1.523E-01	PRKCA
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4.018E-02	1.523E-01	PRKCA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4.981E-03	9.318E-02	MMP2, PRKCA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.776E-03	9.318E-02	PTPN1, PTPRF

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Notholaena lemmonii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities