CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.710E-12	5.900E-08	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.914E-12	6.438E-08	CA1, CA12, CA5A, CA5B, CA6, L3MBTL1, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.353E-10	1.825E-06	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.605E-10	4.183E-06	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.375E-06	6.856E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	3.634E-06	6.856E-03	ACP1, PTPN1, PTPN2, PTPRF
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.375E-06	6.856E-03	GPBAR1, NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	4.687E-12	3.890E-10	CA12; CA1; CA5B; CA5A; CA6
hsa04520	Adherens junction_Homo sapiens_hsa04520	6.164E-05	2.558E-03	PTPN1; ACP1; PTPRF

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12; MMP12
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2
C00-D49: Neoplasms	Cancer	C00-C96	CA1; MMP2
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1; MMP12
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2
NA: NA	Colour dead tissues	NA	PTPN1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Notholaena lemmonii

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases