Plant Name: Senecio chionophilus
Taxonomic Information:
Plant ID: NPO28122
Plant Latin Name: Senecio chionophilus
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; | |
| TSHR; | |
| PTPN1; | |
| BLM; | |
| GRIA4; GRIK2; GRIA1; GRIK3; GRIK5; GRIK1; | |
| SMN1;SMN2; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Ionotropic glutamate receptor | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | P48058 | CHEMBL3190 |
| Ionotropic glutamate receptor | GRIK2 | Glutamate receptor ionotropic kainate 2 | Q13002 | CHEMBL3683 |
| Ionotropic glutamate receptor | GRIA1 | Glutamate receptor ionotropic, AMPA 1 | P42261 | CHEMBL2009 |
| Ionotropic glutamate receptor | GRIK3 | Glutamate receptor ionotropic kainate 3 | Q13003 | CHEMBL3684 |
| Ionotropic glutamate receptor | GRIK5 | Glutamate receptor ionotropic kainate 5 | Q16478 | CHEMBL2675 |
| Ionotropic glutamate receptor | GRIK1 | Glutamate receptor ionotropic kainate 1 | P39086 | CHEMBL1918 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005215; transporter activity | GO:0015277; kainate selective glutamate receptor activity | 6.163E-13 | 1.491E-09 | GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0023052; signaling | GO:0060079; excitatory postsynaptic potential | 2.798E-12 | 5.540E-09 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 8.490E-09 | 1.027E-05 | GRIK2, GRIK3, GRIK5, SMN1, SMN2 |
| MF | GO:0005215; transporter activity | GO:0008381; mechanosensitive ion channel activity | 3.890E-08 | 3.258E-05 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044456; synapse part | GO:0045211; postsynaptic membrane | 1.778E-07 | 1.335E-04 | GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| MF | GO:0005215; transporter activity | GO:0098782; mechanosensitived potassium channel activity | 7.897E-07 | 4.777E-04 | GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0032991; macromolecular complex | GO:0032983; kainate selective glutamate receptor complex | 1.254E-06 | 6.561E-04 | GRIK2, GRIK5 |
| MF | Unclassified; | GO:0004872; receptor activity | 1.544E-06 | 7.473E-04 | ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR |
| MF | GO:0005215; transporter activity | GO:0004971; AMPA glutamate receptor activity | 2.507E-06 | 1.137E-03 | GRIA1, GRIA4 |
| CC | GO:0044464; cell part | GO:0043005; neuron projection | 6.386E-06 | 2.528E-03 | GRIA1, GRIA4, GRIK3, GRIK5, SMN1, SMN2 |
| CC | GO:0044456; synapse part | GO:0043195; terminal bouton | 8.802E-06 | 3.305E-03 | GRIK2, GRIK3, GRIK5 |
| BP | GO:0051179; localization | GO:0034220; ion transmembrane transport | 1.130E-05 | 4.035E-03 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| MF | GO:0005488; binding | GO:0030165; PDZ domain binding | 2.360E-05 | 8.029E-03 | GRIA1, GRIK2, GRIK5 |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 2.749E-05 | 9.210E-03 | SMN1, SMN2 |
| MF | GO:0005215; transporter activity | GO:0005234; extracellularly glutamate-gated ion channel activity | 6.433E-16 | 7.004E-12 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0009987; cellular process | GO:0035235; ionotropic glutamate receptor signaling pathway | 5.447E-15 | 3.811E-11 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0023052; signaling | GO:0051967; negative regulation of synaptic transmission, glutamatergic | 3.788E-05 | 1.115E-02 | GRIK2, GRIK3 |
| BP | GO:0032501; multicellular organismal process | GO:0007399; nervous system development | 4.930E-05 | 1.394E-02 | GRIK1, SMN1, SMN2, TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 1.484E-12 | 3.858E-11 | GRIA1, GRIK5, ADORA3, GRIK3, GRIK1, GRIK2, TSHR, GRIA4 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04724 | Glutamatergic synapse | 4.988E-11 | 6.484E-10 | GRIA1, GRIK5, GRIK3, GRIK1, GRIK2, GRIA4 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 2.578E-04 | 1.950E-03 | GRIA1, TSHR, GRIA4 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05033 | Nicotine addiction | 3.000E-04 | 1.950E-03 | GRIA1, GRIA4 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05031 | Amphetamine addiction | 8.420E-04 | 4.379E-03 | GRIA1, GRIA4 |
| 09150 Organismal Systems | 09159 Environmental adaptation | hsa04713 | Circadian entrainment | 1.683E-03 | 7.055E-03 | GRIA1, GRIA4 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 1.899E-03 | 7.055E-03 | GRIA1, GRIA4 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04728 | Dopaminergic synapse | 3.074E-03 | 9.989E-03 | GRIA1, GRIA4 |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 5.389E-03 | 1.557E-02 | SMN2, SMN1 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03440 | Homologous recombination | 1.869E-02 | 4.860E-02 | BLM |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | ADORA3; |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | GRIK1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | GRIK1; |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3; |
| C00-D49: Neoplasms | Cancer | C00-C96 | ADORA3; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | GRIK1; |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | GRIK1; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3; |
| NA: NA | Hepatitis C virus infection | NA | ADORA3; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ADORA3; |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ADORA3; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | GRIK1; |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ADORA3; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
