Plant Name: Senecio chionophilus
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0023052; signaling | GO:0060079; excitatory postsynaptic potential | 2.798E-12 | 5.540E-09 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0051179; localization | GO:0034220; ion transmembrane transport | 1.130E-05 | 4.035E-03 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0009987; cellular process | GO:0035235; ionotropic glutamate receptor signaling pathway | 5.447E-15 | 3.811E-11 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 8.490E-09 | 1.027E-05 | GRIK2, GRIK3, GRIK5, SMN1, SMN2 |
| CC | GO:0044456; synapse part | GO:0045211; postsynaptic membrane | 1.778E-07 | 1.335E-04 | GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0032991; macromolecular complex | GO:0032983; kainate selective glutamate receptor complex | 1.254E-06 | 6.561E-04 | GRIK2, GRIK5 |
| CC | GO:0044464; cell part | GO:0043005; neuron projection | 6.386E-06 | 2.528E-03 | GRIA1, GRIA4, GRIK3, GRIK5, SMN1, SMN2 |
| CC | GO:0044456; synapse part | GO:0043195; terminal bouton | 8.802E-06 | 3.305E-03 | GRIK2, GRIK3, GRIK5 |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 2.749E-05 | 9.210E-03 | SMN1, SMN2 |
| MF | GO:0005215; transporter activity | GO:0015277; kainate selective glutamate receptor activity | 6.163E-13 | 1.491E-09 | GRIK1, GRIK2, GRIK3, GRIK5 |
Showing 1 to 10 of 17 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 5.389E-03 | 1.557E-02 | SMN2; SMN1 |
| hsa03440 | Homologous recombination_Homo sapiens_hsa03440 | 1.869E-02 | 4.860E-02 | BLM |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 2.578E-04 | 1.950E-03 | GRIA1; TSHR; GRIA4 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.484E-12 | 3.858E-11 | GRIA1; GRIK5; ADORA3; GRIK3; GRIK1; GRIK2; TSHR; GRIA4 |
| hsa04713 | Circadian entrainment_Homo sapiens_hsa04713 | 1.683E-03 | 7.055E-03 | GRIA1; GRIA4 |
| hsa04723 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.899E-03 | 7.055E-03 | GRIA1; GRIA4 |
| hsa04724 | Glutamatergic synapse_Homo sapiens_hsa04724 | 4.988E-11 | 6.484E-10 | GRIA1; GRIK5; GRIK3; GRIK1; GRIK2; GRIA4 |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 3.074E-03 | 9.989E-03 | GRIA1; GRIA4 |
| hsa05031 | Amphetamine addiction_Homo sapiens_hsa05031 | 8.420E-04 | 4.379E-03 | GRIA1; GRIA4 |
| hsa05033 | Nicotine addiction_Homo sapiens_hsa05033 | 3.000E-04 | 1.950E-03 | GRIA1; GRIA4 |
Showing 1 to 10 of 10 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Cancer | C00-C96 | ADORA3 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ADORA3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1 |
Showing 1 to 10 of 26 entries