CMAUP Plant Collective Molecular Activities

Plant Name: Maclura tinctoria

Taxonomic Information:

Plant ID: NPO27239
Plant Latin Name: Maclura tinctoria
Taxonomy Genus: Maclura
Taxonomy Family: Moraceae

Plant External Links:

NCBI TaxonomyDB: 681456
Plant-of-the-World-Online: 1151750-2

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Brazil; Jamaica; Belize; Honduras; Peru; Cuba; El Salvador; Venezuela; Mexico; Costa Rica; Trinidad and Tobago; Guatemala; Netherlands; China; Colombia; Paraguay; Dominican Republic; Bolivia; Nicaragua; Haiti

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	RECQL; TDP1; BLM; HSD17B1; HSD17B10; ALOX15;
Protein Kinase	MAPK1; PIM1; CSNK2A1;
Lyase	CA2; CA1; CA12; CA9; CA5A; CA3; CA14; CA7; CA4; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Serine protease	ELANE;
Transcription Factor	HIF1A;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP19A1; CYP3A4; CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Serine protease	ELANE	Leukocyte elastase	P08246	CHEMBL248
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.923E-09	4.188E-06	BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9, ESR1, ESR2
MF	GO:0005488; binding	GO:0019825; oxygen binding	8.862E-09	1.608E-05	CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.461E-08	1.083E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.824E-07	2.336E-04	ALOX15, CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.433E-07	2.944E-04	CYP19A1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.457E-07	4.412E-04	CYP1B1, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	8.154E-07	7.398E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.667E-26	1.452E-21	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0020037; heme binding	1.748E-06	1.464E-03	CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	2.493E-06	1.969E-03	ESR1, ESR2
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.881E-06	3.322E-03	CYP1B1, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.486E-06	4.280E-03	CYP19A1, CYP1B1, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.471E-06	4.648E-03	CA2, CA7
MF	GO:0005488; binding	GO:0005496; steroid binding	1.051E-05	6.073E-03	CYP3A4, ESR1, ESR2, HSD17B1
BP	GO:0008152; metabolic process	GO:0008209; androgen metabolic process	1.193E-05	6.496E-03	CYP19A1, CYP3A4, ESR1
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	1.422E-05	7.066E-03	ALOX15, BLM, CA2, CA9, CYP1B1, HIF1A, LMNA, MAPK1, MAPT, RECQL, TDP1
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	1.493E-05	7.066E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.493E-05	7.066E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	1.799E-05	8.160E-03	CSNK2A1, HIF1A, MAPT
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.353E-20	5.828E-16	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.793E-18	9.760E-15	CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.673E-04	4.496E-02	HIF1A, MAPK1, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.043E-25	3.774E-23	CA12, CA1, CA3, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.091E-07	6.767E-06	CYP2C9, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.890E-06	7.810E-05	HSD17B1, CYP1B1, CYP3A4, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.590E-06	2.353E-04	CYP2C9, CYP1B1, CYP3A4, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.609E-05	6.471E-04	CYP2C9, ALOX15, MAPK1, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.290E-05	1.300E-03	HSD17B1, CYP1B1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.199E-04	2.123E-03	CYP2C9, ALOX15, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.870E-04	2.416E-03	MAPK1, ESR1, ESR2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.648E-04	2.416E-03	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.949E-04	2.416E-03	CYP2C9, CYP1B1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	4.782E-04	5.390E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	7.977E-04	7.609E-03	MAPK1, ESR1, HIF1A
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.764E-04	5.957E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases