CMAUP Plant Collective Molecular Activities

Plant Name: Echinochloa crus-galli

Taxonomic Information:

Plant ID: NPO26873
Plant Latin Name: Echinochloa crus-galli
Taxonomy Genus: Echinochloa
Taxonomy Family: Poaceae

Plant External Links:

NCBI TaxonomyDB: 90397
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Jordan; India

Traditional Medicine System:

Indian Folk

Medicinal Functions:

Styptic; Tonic

Geographical Distribution:

Jordan; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B; PTPN11;
Enzyme_unclassified	ALPL; PLA2G1B; TERT; HSD17B10; AKR1B10; POLB;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	NFKB1;
Unclassified	HSF1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Protein Phosphatase	PTPN11	Protein-tyrosine phosphatase 2C	Q06124	CHEMBL3864
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	HSF1	Heat shock factor protein 1	Q00613	CHEMBL5869

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	8.485E-07	5.208E-03	CDC25B, PTPN1, PTPN11, PTPN2
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.688E-06	5.250E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.688E-06	5.250E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	3.374E-06	7.819E-03	PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:0045931; positive regulation of mitotic cell cycle	3.794E-06	7.819E-03	CDC25B, HSF1, PTPN11, TERT
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	5.637E-06	7.819E-03	PTPN1, PTPN11, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	6.832E-06	7.830E-03	NR1H4, PTPN1, PTPN2
MF	GO:0005488; binding	GO:0097677; STAT family protein binding	8.428E-06	8.739E-03	HSF1, PTPN2
MF	GO:0005488; binding	GO:0030971; receptor tyrosine kinase binding	1.025E-05	9.329E-03	PTPN1, PTPN11, PTPN2
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	1.572E-05	1.167E-02	PTPN11, PTPN2
MF	GO:0005488; binding	GO:0032052; bile acid binding	2.020E-05	1.375E-02	NR1H4, PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	6.831E-05	5.601E-03	PTPN1, PTPN11, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	5.936E-04	1.371E-02	PLA2G1B, PTPN11, NFKB1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.256E-04	9.251E-03	AKR1B10, GAA
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	8.607E-04	1.371E-02	POLB, TERT, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	7.620E-04	1.371E-02	HSF1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.162E-03	1.371E-02	PTPN11, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.610E-03	1.467E-02	AKR1B10, PLA2G1B, GAA, ALPL, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.338E-03	1.371E-02	PTPN11, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.231E-03	1.371E-02	PTPN11, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	3.562E-03	2.921E-02	PTPN11, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Multiple myeloma	C90	TERT;
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; CDC25B;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT;
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT;
C00-D49: Neoplasms	Breast cancer	C50	TERT;
C00-D49: Neoplasms	Prostate cancer	C61	TERT;
C00-D49: Neoplasms	Tumors	C00-D48	TERT;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Liver cancer	C22	TERT;
C00-D49: Neoplasms	Melanoma	C43	TERT;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Ovarian cancer	C56	TERT;
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases