Plant Name: Echinochloa crus-galli
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 8.485E-07 | 5.208E-03 | CDC25B, PTPN1, PTPN11, PTPN2 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.688E-06 | 5.250E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.688E-06 | 5.250E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 3.374E-06 | 7.819E-03 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:0045931; positive regulation of mitotic cell cycle | 3.794E-06 | 7.819E-03 | CDC25B, HSF1, PTPN11, TERT |
| BP | GO:0009987; cellular process | GO:0060338; regulation of type I interferon-mediated signaling pathway | 5.637E-06 | 7.819E-03 | PTPN1, PTPN11, PTPN2 |
| BP | Unclassified; | GO:1905953; negative regulation of lipid localization | 6.018E-06 | 7.819E-03 | NFKB1, PTPN11, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 6.832E-06 | 7.830E-03 | NR1H4, PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0097677; STAT family protein binding | 8.428E-06 | 8.739E-03 | HSF1, PTPN2 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 1.025E-05 | 9.329E-03 | PTPN1, PTPN11, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 6.831E-05 | 5.601E-03 | PTPN1; PTPN11; NFKB1 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 5.936E-04 | 1.371E-02 | PLA2G1B; PTPN11; NFKB1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 2.256E-04 | 9.251E-03 | AKR1B10; GAA |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 8.607E-04 | 1.371E-02 | POLB; TERT; NFKB1 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 7.620E-04 | 1.371E-02 | HSF1; NFKB1 |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.162E-03 | 1.371E-02 | PTPN11; NFKB1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.610E-03 | 1.467E-02 | AKR1B10; PLA2G1B; GAA; ALPL; HSD17B10 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.338E-03 | 1.371E-02 | PTPN11; NFKB1 |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.231E-03 | 1.371E-02 | PTPN11; NFKB1 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 3.562E-03 | 2.921E-02 | PTPN11; NFKB1 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 6.087E-03 | 4.537E-02 | PTPN11; PTPN2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | HSF1 |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | HSF1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSF1 |
| C00-D49: Neoplasms | Metastasis | C00-C97 | HSF1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; CDC25B; HSF1 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | HSF1 |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | PLA2G1B |
| C00-D49: Neoplasms | Breast cancer | C50 | TERT |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| A00-B99: Certain infectious and parasitic diseases | Herpes simplex virus infection | B00 | HSF1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B |
| C00-D49: Neoplasms | Prostate cancer | C61 | TERT |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; NFKB1; GPBAR1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| C00-D49: Neoplasms | Leukemia | C90-C95 | HSF1 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | Melanoma | C43 | TERT |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT |