CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL; ALPL; TDP1; ALOX12; HSD17B10; ALOX15; APEX1; POLB;
Hydrolase	GAA; ACHE;
Protein Kinase	CDK2; CDK6;
Lyase	CA2; CA1; CA12; CA9; CA14; CA5A; CA3; CA7; CA6;
Aspartic protease	BACE1;
Transcription Factor	NFKB1;
ATP-binding cassette	ABCG2; ABCC1;
Oxidoreductase	XDH;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	5.871E-07	8.522E-04	ABCC1, ABCG2, APEX1, CA3, CA9, CDK2, CDK6, NFKB1, POLB
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	2.026E-06	1.838E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	2.026E-06	1.838E-03	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.074E-06	4.408E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	1.193E-05	7.772E-03	ABCC1, ALOX12, ALOX15
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.610E-18	3.346E-14	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.910E-16	8.317E-13	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	2.026E-06	1.838E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	6.074E-06	4.408E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	6.074E-06	4.408E-03	ALOX12, ALOX15

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.184E-22	1.042E-20	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	9.715E-04	1.602E-02	POLB, APEX1
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.724E-03	1.686E-02	ABCC1, ABCG2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.425E-03	2.936E-02	CA2, ABCG2
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.810E-04	6.825E-03	POLB, CDK6, CDK2, NFKB1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	2.327E-04	6.825E-03	CDK6, CDK2, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	8.896E-04	1.602E-02	CDK6, CDK2, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.092E-03	1.602E-02	CDK6, CDK2, NFKB1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.634E-03	1.686E-02	BACE1, MAPT, HSD17B10
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.288E-03	1.620E-02	GAA, ALOX15, ALPL, ALOX12, CYP19A1, HSD17B10, XDH

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ACHE;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;

Showing 1 to 10 of 27 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Lachnophyllum gossypinum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities