Plant Name: Lachnophyllum gossypinum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 5.871E-07 | 8.522E-04 | ABCC1, ABCG2, APEX1, CA3, CA9, CDK2, CDK6, NFKB1, POLB |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.026E-06 | 1.838E-03 | APEX1, POLB |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.026E-06 | 1.838E-03 | ALOX12, ALOX15 |
| BP | GO:0065007; biological regulation | GO:0065008; regulation of biological quality | 2.393E-06 | 2.084E-03 | ABCC1, ABCG2, ACHE, ALOX12, ALOX15, APEX1, CA12, CA2, CA7, CDK6, CYP19A1, GAA, MAPT, NFKB1, POLB, XDH |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 6.074E-06 | 4.408E-03 | CA2, CA7 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 1.193E-05 | 7.772E-03 | ABCC1, ALOX12, ALOX15 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.610E-18 | 3.346E-14 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.910E-16 | 8.317E-13 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.026E-06 | 1.838E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 6.074E-06 | 4.408E-03 | ALOX12, ALOX15 |
Showing 1 to 10 of 13 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 6.981E-03 | 3.840E-02 | XDH |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 3.393E-03 | 2.936E-02 | ALOX15; ALOX12 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.184E-22 | 1.042E-20 | CA12; CA1; CA3; CA2; CA5A; CA7; CA6; CA9; CA14 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.288E-03 | 1.620E-02 | GAA; ALOX15; ALPL; ALOX12; CYP19A1; HSD17B10; XDH |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 1.724E-03 | 1.686E-02 | ABCC1; ABCG2 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 9.715E-04 | 1.602E-02 | POLB; APEX1 |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 4.184E-03 | 2.936E-02 | CDK6; CDK2 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 4.425E-03 | 2.936E-02 | CA2; ABCG2 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.634E-03 | 1.686E-02 | BACE1; MAPT; HSD17B10 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 1.092E-03 | 1.602E-02 | CDK6; CDK2; NFKB1 |
Showing 1 to 10 of 17 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CDK2 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CDK2 |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2 |
Showing 1 to 10 of 53 entries