CMAUP Plant Collective Molecular Activities

Plant Name: Piper methysticum

Taxonomic Information:

Plant ID: NPO26193
Plant Latin Name: Piper methysticum
Taxonomy Genus: Piper
Taxonomy Family: Piperaceae

Plant External Links:

NCBI TaxonomyDB: 130404
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; China

Traditional Medicine System:

TCM

Geographical Distribution:

Indonesia; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD1; DRD2;
Hydrolase	BCHE; ACHE;
Enzyme_unclassified	MTOR; PKM; ALOX15;
Transcription Factor	NFKB1; HIF1A; STAT6; TP53;
ATP-binding cassette	ABCG2;
Unclassified	HTT; THPO; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2D6; CYP3A4; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	STAT6	Signal transducer and activator of transcription 6	P42226	CHEMBL5401
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.546E-11	3.367E-07	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0042802; identical protein binding	1.791E-08	7.802E-05	ABCG2, ACHE, BCHE, DRD2, HTT, MTOR, NFKB1, PKM, SMN1, SMN2, STAT6, TP53
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.237E-07	3.253E-04	BCHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.494E-07	3.253E-04	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0007610; behavior	GO:0008542; visual learning	1.947E-07	3.533E-04	DRD1, DRD2, HIF1A, MTOR
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.421E-07	3.649E-04	CYP1A2, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.421E-07	3.649E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0023052; signaling	GO:0050805; negative regulation of synaptic transmission	6.286E-07	5.704E-04	ACHE, BCHE, DRD1, DRD2
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.696E-07	5.832E-04	ALOX15, CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.126E-06	7.934E-04	ACHE, BCHE
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.934E-06	1.239E-03	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	3.375E-06	1.837E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	4.423E-06	2.189E-03	HIF1A, LMNA, MTOR, TP53
BP	GO:0008152; metabolic process	GO:0046483; heterocycle metabolic process	5.296E-06	2.453E-03	ABCG2, ACHE, BCHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4, HIF1A, MTOR, NFKB1, PKM, SMN1, SMN2, STAT6, TP53
BP	GO:0008152; metabolic process	GO:0006725; cellular aromatic compound metabolic process	5.908E-06	2.573E-03	ABCG2, ACHE, BCHE, CYP1A2, CYP2D6, DRD1, DRD2, HIF1A, MTOR, NFKB1, PKM, SMN1, SMN2, STAT6, TP53
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.485E-06	2.720E-03	CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.746E-06	2.720E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.009E-05	3.543E-03	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	1.124E-05	3.734E-03	DRD1, DRD2
BP	GO:0023052; signaling	GO:0051584; regulation of dopamine uptake involved in synaptic transmission	3.140E-05	8.043E-03	DRD1, DRD2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	3.749E-05	9.277E-03	ABCG2, CYP1A2, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, HTT, LMNA, MTOR, STAT6
CC	GO:0044464; cell part	GO:0042995; cell projection	6.074E-05	1.197E-02	DRD1, DRD2, HIF1A, HTT, MTOR, PKM, SMN1, SMN2
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	7.381E-05	1.356E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	8.718E-05	1.507E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	1.704E-04	2.525E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.097E-08	2.411E-06	CYP1A2, ALOX15, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	6.594E-07	2.847E-05	PKM, TP53, HIF1A, MTOR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.427E-07	2.847E-05	CYP2D6, CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	1.782E-05	5.123E-04	DRD1, DRD2, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.919E-05	1.361E-03	CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.069E-04	1.756E-03	TP53, NFKB1, MTOR
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.258E-04	1.808E-03	TP53, NFKB1, MTOR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.376E-05	1.605E-03	CYP1A2, CYP3A4, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.649E-04	2.107E-03	HIF1A, NFKB1, MTOR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.113E-04	2.429E-03	CYP2D6, ALOX15, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.464E-04	2.576E-03	TP53, HIF1A, MTOR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.071E-04	3.901E-03	LMNA, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	7.002E-04	5.369E-03	HIF1A, TP53, NFKB1, MTOR
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	4.602E-04	4.071E-03	STAT6, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	5.795E-04	4.760E-03	THPO, STAT6, MTOR
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.197E-03	7.455E-03	TP53, HIF1A, MTOR
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.131E-03	7.455E-03	DRD1, DRD2, NFKB1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.232E-03	7.455E-03	PKM, TP53, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	1.150E-03	7.455E-03	PKM, MTOR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.619E-03	9.174E-03	NFKB1, MTOR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	2.099E-03	9.213E-03	TP53, MTOR
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	1.792E-03	9.213E-03	HIF1A, MTOR
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.912E-03	9.213E-03	ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	2.163E-03	9.213E-03	TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.675E-03	9.174E-03	CYP1A2, CYP3A4
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	2.099E-03	9.213E-03	STAT6, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.099E-03	9.213E-03	CYP1A2, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	2.429E-03	9.906E-03	NFKB1, MTOR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.498E-03	9.906E-03	CYP3A4, ABCG2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
NA: NA	Hyperaemia	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
NA: NA	Vomiting	NA	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD2;
NA: NA	Corneal vascularity	NA	DRD2;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2;
NA: NA	Malignant essential hypertension	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; DRD2;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1; DRD2;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
NA: NA	False perceptions	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; DRD1; DRD2;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE; DRD2;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; DRD1; DRD2;
J00-J99: Diseases of the respiratory system	Asthma	J45	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1; DRD2;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	DRD2;
NA: NA	Inflammatory diseases	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	DRD2;
NA: NA	Schizoaffective disorders	NA	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
NA: NA	Itching	NA	DRD2;
C00-D49: Neoplasms	Breast cancer	C50	DRD2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1; DRD2;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases