CMAUP Plant Collective Molecular Activities

Plant Name: Piper methysticum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.546E-11	3.367E-07	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0042802; identical protein binding	1.791E-08	7.802E-05	ABCG2, ACHE, BCHE, DRD2, HTT, MTOR, NFKB1, PKM, SMN1, SMN2, STAT6, TP53
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.237E-07	3.253E-04	BCHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.494E-07	3.253E-04	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0007610; behavior	GO:0008542; visual learning	1.947E-07	3.533E-04	DRD1, DRD2, HIF1A, MTOR
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.421E-07	3.649E-04	CYP1A2, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.421E-07	3.649E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0023052; signaling	GO:0050805; negative regulation of synaptic transmission	6.286E-07	5.704E-04	ACHE, BCHE, DRD1, DRD2
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.696E-07	5.832E-04	ALOX15, CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.126E-06	7.934E-04	ACHE, BCHE
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.934E-06	1.239E-03	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	3.375E-06	1.837E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	4.423E-06	2.189E-03	HIF1A, LMNA, MTOR, TP53
BP	GO:0008152; metabolic process	GO:0046483; heterocycle metabolic process	5.296E-06	2.453E-03	ABCG2, ACHE, BCHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4, HIF1A, MTOR, NFKB1, PKM, SMN1, SMN2, STAT6, TP53
BP	GO:0008152; metabolic process	GO:0006725; cellular aromatic compound metabolic process	5.908E-06	2.573E-03	ABCG2, ACHE, BCHE, CYP1A2, CYP2D6, DRD1, DRD2, HIF1A, MTOR, NFKB1, PKM, SMN1, SMN2, STAT6, TP53
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.485E-06	2.720E-03	CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.746E-06	2.720E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.009E-05	3.543E-03	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	1.124E-05	3.734E-03	DRD1, DRD2
BP	GO:0023052; signaling	GO:0051584; regulation of dopamine uptake involved in synaptic transmission	3.140E-05	8.043E-03	DRD1, DRD2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	3.749E-05	9.277E-03	ABCG2, CYP1A2, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, HTT, LMNA, MTOR, STAT6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.097E-08	2.411E-06	CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	6.594E-07	2.847E-05	PKM; TP53; HIF1A; MTOR
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	7.427E-07	2.847E-05	CYP2D6; CYP1A2; CYP3A4; CYP2C19
hsa05030	Cocaine addiction_Homo sapiens_hsa05030	1.782E-05	5.123E-04	DRD1; DRD2; NFKB1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.919E-05	1.361E-03	CYP2D6; CYP1A2; CYP3A4
hsa05215	Prostate cancer_Homo sapiens_hsa05215	1.069E-04	1.756E-03	TP53; NFKB1; MTOR
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.258E-04	1.808E-03	TP53; NFKB1; MTOR
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	8.376E-05	1.605E-03	CYP1A2; CYP3A4; CYP2C19
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.649E-04	2.107E-03	HIF1A; NFKB1; MTOR
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	2.113E-04	2.429E-03	CYP2D6; ALOX15; CYP2C19
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	2.464E-04	2.576E-03	TP53; HIF1A; MTOR
hsa04210	Apoptosis_Homo sapiens_hsa04210	4.071E-04	3.901E-03	LMNA; TP53; NFKB1
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	7.002E-04	5.369E-03	HIF1A; TP53; NFKB1; MTOR
hsa05161	Hepatitis B_Homo sapiens_hsa05161	4.602E-04	4.071E-03	STAT6; TP53; NFKB1
hsa04630	Jak-STAT signaling pathway_Homo sapiens_hsa04630	5.795E-04	4.760E-03	THPO; STAT6; MTOR
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	1.197E-03	7.455E-03	TP53; HIF1A; MTOR
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	1.131E-03	7.455E-03	DRD1; DRD2; NFKB1
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	1.232E-03	7.455E-03	PKM; TP53; NFKB1
hsa04930	Type II diabetes mellitus_Homo sapiens_hsa04930	1.150E-03	7.455E-03	PKM; MTOR
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	1.619E-03	9.174E-03	NFKB1; MTOR
hsa05214	Glioma_Homo sapiens_hsa05214	2.099E-03	9.213E-03	TP53; MTOR
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	1.792E-03	9.213E-03	HIF1A; MTOR
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.912E-03	9.213E-03	ALOX15; CYP2C19
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	3.536E-03	1.308E-02	TP53; NFKB1; MTOR
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	2.163E-03	9.213E-03	TP53; NFKB1
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.675E-03	9.174E-03	CYP1A2; CYP3A4
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	5.203E-03	1.674E-02	TP53; NFKB1; MTOR
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.099E-03	9.213E-03	STAT6; NFKB1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.099E-03	9.213E-03	CYP1A2; CYP3A4
hsa05220	Chronic myeloid leukemia_Homo sapiens_hsa05220	2.638E-03	1.011E-02	TP53; NFKB1
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	2.429E-03	9.906E-03	NFKB1; MTOR
hsa05231	Choline metabolism in cancer_Homo sapiens_hsa05231	4.981E-03	1.674E-02	HIF1A; MTOR
hsa05222	Small cell lung cancer_Homo sapiens_hsa05222	3.639E-03	1.308E-02	TP53; NFKB1
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	7.999E-03	2.244E-02	PKM; CYP1A2; ALOX15; CYP2C19; CYP3A4
hsa04976	Bile secretion_Homo sapiens_hsa04976	2.498E-03	9.906E-03	CYP3A4; ABCG2
hsa04540	Gap junction_Homo sapiens_hsa04540	3.807E-03	1.327E-02	DRD1; DRD2
hsa04931	Insulin resistance_Homo sapiens_hsa04931	5.776E-03	1.795E-02	NFKB1; MTOR
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	6.959E-03	2.052E-02	TP53; NFKB1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	6.959E-03	2.052E-02	TP53; NFKB1
hsa04728	Dopaminergic synapse_Homo sapiens_hsa04728	8.001E-03	2.244E-02	DRD1; DRD2
hsa05162	Measles_Homo sapiens_hsa05162	8.857E-03	2.369E-02	TP53; NFKB1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	8.485E-03	2.323E-02	TP53; NFKB1
hsa05012	Parkinson's disease_Homo sapiens_hsa05012	9.622E-03	2.515E-02	DRD1; DRD2
hsa03013	RNA transport_Homo sapiens_hsa03013	1.387E-02	3.545E-02	SMN2; SMN1
hsa05034	Alcoholism_Homo sapiens_hsa05034	1.496E-02	3.699E-02	DRD1; DRD2
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.879E-02	4.322E-02	TP53; NFKB1
hsa05016	Huntington's disease_Homo sapiens_hsa05016	1.725E-02	4.048E-02	HTT; TP53
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.512E-02	3.699E-02	TP53; NFKB1
hsa05168	Herpes simplex infection_Homo sapiens_hsa05168	1.592E-02	3.815E-02	TP53; NFKB1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	5.240E-03	1.674E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2; DRD2; DRD2; DRD2
C00-D49: Neoplasms	Bladder cancer	C67	MTOR
NA: NA	Benign prostatic hypertrophy	NA	DRD2
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2
NA: NA	Hyperaemia	NA	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR
NA: NA	Vomiting	NA	DRD2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MTOR
NA: NA	Upper abdominal bloating	NA	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
C00-D49: Neoplasms	Solid tumors	NA	MTOR
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1; NFKB1
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; MTOR; PKM; HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD2
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
NA: NA	Coronary artery restenosis	NA	MTOR
NA: NA	Corneal vascularity	NA	DRD2
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	DRD2
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MTOR; DRD2
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
NA: NA	Malignant essential hypertension	NA	DRD2
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Organ rejection	D89.8, T86	MTOR
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	DRD2; ACHE; ACHE; ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1; DRD2; DRD2; DRD2; DRD2
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2
C00-D49: Neoplasms	Multiple myeloma	C90	MTOR; MTOR
NA: NA	False perceptions	NA	DRD2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	MTOR; PKM; DRD1; DRD2; ACHE
C00-D49: Neoplasms	Pancreatic cancer	C25	MTOR
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; DRD2; ACHE
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR
C00-D49: Neoplasms	Cancer	C00-C96	TP53; MTOR; HIF1A; NFKB1; ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1; DRD2; ACHE
J00-J99: Diseases of the respiratory system	Asthma	J45	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MTOR
C00-D49: Neoplasms	Renal cancer	C64	MTOR
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1; DRD2
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2
NA: NA	Peripheral vasoconstriction	NA	DRD2
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
NA: NA	Malignant phaeochromocytoma	NA	DRD2
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	DRD2
C00-D49: Neoplasms	Lymphoma	C81-C86	MTOR; HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	DRD2; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR; DRD2
NA: NA	Inflammatory diseases	NA	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; DRD2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	DRD2
NA: NA	Schizoaffective disorders	NA	DRD2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2
NA: NA	Itching	NA	DRD2
C00-D49: Neoplasms	Breast cancer	C50	DRD2
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Transplant rejection	D89.8, T86	MTOR
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1; DRD2; DRD2
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases