CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	FAAH; TERT; ALOX15; HPGD; ALDH1A1;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA; PPARG;
Unclassified	MAPT; FABP3; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963

Showing 1 to 10 of 16 entries

Previous1 2Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015908; fatty acid transport	2.332E-07	5.077E-04	FABP3, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	2.053E-06	2.353E-03	FFAR4, PPARA, PPARD, PPARG
BP	GO:0008283; cell proliferation	GO:0048660; regulation of smooth muscle cell proliferation	3.148E-06	2.742E-03	HPGD, PPARD, PPARG, TERT
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	6.423E-06	5.180E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	9.631E-06	5.519E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	9.631E-06	5.519E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	9.631E-06	5.519E-03	ALOX15, HPGD
BP	GO:0008152; metabolic process	GO:0044242; cellular lipid catabolic process	1.040E-05	5.661E-03	FAAH, FABP3, FABP5, PPARD
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	1.127E-05	5.986E-03	ALOX15, CYP2A6, FAAH
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	8.394E-06	5.519E-03	PPARA, PPARD, PPARG

Showing 1 to 10 of 14 entries

Previous1 2Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.212E-03	2.363E-02	CYP2A6, ALDH1A1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.994E-03	5.192E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3.619E-02	1.168E-01	CYP2A6
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.848E-02	1.168E-01	ALOX15
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5.381E-02	1.168E-01	CYP2A6
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.078E-02	8.412E-02	PPARA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.788E-09	6.975E-08	FABP3, FABP5, PPARG, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4.389E-02	1.168E-01	TSHR
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	8.897E-03	8.412E-02	HPGD, PPARG
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	4.465E-02	1.168E-01	PPARD

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;

Showing 1 to 3 of 3 entries

Previous1Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Prunus mandshurica

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities