Plant Name: Prunus mandshurica
Taxonomic Information:
Plant ID: NPO25099
Plant Latin Name: Prunus mandshurica
Taxonomy Genus: Prunus
Taxonomy Family: Rosaceae
Plant External Links:
NCBI TaxonomyDB:
122122
Plant-of-the-World-Online:
729939-1
Used in Medicines:
Unknown.
Geographical Distribution:
Russia; South Africa
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; | |
| TSHR; | |
| FAAH; TERT; ALOX15; HPGD; ALDH1A1; | |
| PPARD; PPARA; PPARG; | |
| MAPT; FABP3; LMNA; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2A6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 2.332E-07 | 5.077E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 2.053E-06 | 2.353E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0008283; cell proliferation | GO:0048660; regulation of smooth muscle cell proliferation | 3.148E-06 | 2.742E-03 | HPGD, PPARD, PPARG, TERT |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 6.423E-06 | 5.180E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 5.519E-03 | ALOX15, HPGD |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 8.394E-06 | 5.519E-03 | PPARA, PPARD, PPARG |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 9.631E-06 | 5.519E-03 | FABP3, PPARG |
| BP | GO:0008152; metabolic process | GO:0044242; cellular lipid catabolic process | 1.040E-05 | 5.661E-03 | FAAH, FABP3, FABP5, PPARD |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 1.127E-05 | 5.986E-03 | ALOX15, CYP2A6, FAAH |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.474E-05 | 7.640E-03 | PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 2.884E-05 | 1.427E-02 | HPGD, PPARG |
| MF | GO:0005488; binding | GO:0001223; transcription coactivator binding | 1.212E-04 | 2.964E-02 | PPARA, TERT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.788E-09 | 6.975E-08 | FABP3, FABP5, PPARG, PPARA, PPARD |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.212E-03 | 2.363E-02 | CYP2A6, ALDH1A1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.078E-02 | 8.412E-02 | PPARA, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 8.897E-03 | 8.412E-02 | HPGD, PPARG |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 3.994E-03 | 5.192E-02 | CYP2A6 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00983 | Drug metabolism - other enzymes | 3.619E-02 | 1.168E-01 | CYP2A6 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 4.465E-02 | 1.168E-01 | PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 4.389E-02 | 1.168E-01 | TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 4.848E-02 | 1.168E-01 | ALOX15 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 5.381E-02 | 1.168E-01 | CYP2A6 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
