Plant Name: Prunus mandshurica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 2.332E-07 | 5.077E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 2.053E-06 | 2.353E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0008283; cell proliferation | GO:0048660; regulation of smooth muscle cell proliferation | 3.148E-06 | 2.742E-03 | HPGD, PPARD, PPARG, TERT |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 6.423E-06 | 5.180E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 5.519E-03 | ALOX15, HPGD |
| BP | GO:0008152; metabolic process | GO:0044242; cellular lipid catabolic process | 1.040E-05 | 5.661E-03 | FAAH, FABP3, FABP5, PPARD |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 1.127E-05 | 5.986E-03 | ALOX15, CYP2A6, FAAH |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 8.394E-06 | 5.519E-03 | PPARA, PPARD, PPARG |
Showing 1 to 10 of 12 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
| C00-D49: Neoplasms | Prostate cancer | C61 | TERT |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | FAAH |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| C00-D49: Neoplasms | Melanoma | C43 | TERT |
Showing 1 to 10 of 41 entries