CMAUP Plant Collective Molecular Activities

Plant Name: Platymiscium floribundum

Plant ID: NPO24543
Plant Latin Name: Platymiscium floribundum
Taxonomy Genus: Platymiscium
Taxonomy Family: Fabaceae

NCBI TaxonomyDB: 500185
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	GLA; AKR1B1;
Oxidoreductase	ALDH2;
Transcription Factor	NFKB1;
Unclassified	LMNA; RAB9A; NPC1;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C9; CYP19A1; CYP2C19;

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Oxidoreductase	ALDH2	Aldehyde dehydrogenase	P05091	CHEMBL1935
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.660E-09	2.845E-05	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.920E-09	2.845E-05	CYP19A1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.255E-08	6.830E-05	CYP19A1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.017E-08	1.750E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	8.739E-07	2.379E-03	CYP19A1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.121E-06	3.237E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.131E-06	3.237E-03	CYP19A1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0042446; hormone biosynthetic process	6.460E-06	7.934E-03	AKR1B1, CYP19A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.588E-05	1.571E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006066; alcohol metabolic process	1.845E-05	1.607E-02	AKR1B1, ALDH2, CYP3A4, NPC1
CC	GO:0044464; cell part	GO:0005764; lysosome	1.793E-05	1.607E-02	AKR1B1, GLA, NPC1, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.977E-07	5.260E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	5.264E-06	2.316E-04	ALDH2, AKR1B1, GLA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8.456E-06	2.480E-04	CYP2C9, CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.731E-05	6.567E-04	CYP2C9, ALDH2, AKR1B1, CYP2C19, CYP3A4, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.423E-05	3.131E-04	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.056E-04	2.584E-03	ALDH2, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.117E-04	5.915E-03	CYP2C9, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.422E-04	2.086E-03	AKR1B1, GLA
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.354E-04	5.890E-03	CYP3A4, CYP19A1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.722E-04	5.915E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.470E-04	6.776E-03	CYP2C9, CYP3A4

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ALDH2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ALDH2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	ALDH2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases