Plant Name: Platymiscium floribundum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.660E-09 | 2.845E-05 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 3.920E-09 | 2.845E-05 | CYP19A1, CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.255E-08 | 6.830E-05 | CYP19A1, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 4.017E-08 | 1.750E-04 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 8.739E-07 | 2.379E-03 | CYP19A1, CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 2.121E-06 | 3.237E-03 | CYP2C9, CYP3A4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 2.131E-06 | 3.237E-03 | CYP19A1, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0042446; hormone biosynthetic process | 6.460E-06 | 7.934E-03 | AKR1B1, CYP19A1, CYP3A4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 5.977E-07 | 5.260E-05 | CYP2C9; CYP3A4; CYP2C19 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 5.264E-06 | 2.316E-04 | ALDH2; AKR1B1; GLA |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 8.456E-06 | 2.480E-04 | CYP2C9; CYP3A4; CYP2C19 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 3.731E-05 | 6.567E-04 | CYP2C9; ALDH2; AKR1B1; CYP2C19; CYP3A4; CYP19A1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.423E-05 | 3.131E-04 | CYP2C9; CYP3A4; CYP2C19 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.056E-04 | 2.584E-03 | ALDH2; AKR1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 6.117E-04 | 5.915E-03 | CYP2C9; CYP2C19 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.422E-04 | 2.086E-03 | AKR1B1; GLA |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 5.354E-04 | 5.890E-03 | CYP3A4; CYP19A1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 6.722E-04 | 5.915E-03 | CYP2C9; CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 8.470E-04 | 6.776E-03 | CYP2C9; CYP3A4 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.978E-03 | 1.450E-02 | CYP2C9; CYP2C19 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.067E-03 | 1.799E-02 | LMNA; NFKB1 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 2.897E-03 | 1.799E-02 | RAB9A; NFKB1 |
| hsa04142 | Lysosome_Homo sapiens_hsa04142 | 2.378E-03 | 1.610E-02 | NPC1; GLA |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 6.089E-03 | 3.349E-02 | NFKB1; TSHR |
| hsa00603 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 8.370E-03 | 4.333E-02 | GLA |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| E00-E89: Endocrine, nutritional and metabolic diseases | Fabry's disease | E75.2 | GLA |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ALDH2 |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | ALDH2 |
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Substance dependence | F10-F19 | ALDH2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1 |