CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD5; DRD3; DRD4; DRD1; DRD2;
Unclassified	F3; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Small molecule receptor (family A GPCR)	DRD5	Dopamine D5 receptor	P21918	CHEMBL1850
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 7 of 7 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	6.157E-14	3.352E-10	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	2.919E-11	4.539E-08	DRD1, DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007191; adenylate cyclase-activating dopamine receptor signaling pathway	3.493E-09	2.237E-06	DRD1, DRD3, DRD5
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	3.493E-09	2.237E-06	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	4.803E-09	2.988E-06	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	8.322E-09	4.315E-06	DRD1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0060158; phospholipase C-activating dopamine receptor signaling pathway	8.322E-09	4.315E-06	DRD1, DRD2, DRD5
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	5.145E-08	2.197E-05	DRD2, DRD3, DRD4
BP	GO:0065007; biological regulation	GO:0006874; cellular calcium ion homeostasis	5.913E-08	2.476E-05	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0007610; behavior	GO:0046960; sensitization	1.126E-07	3.954E-05	DRD1, DRD5

Showing 1 to 10 of 52 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.009E-08	8.579E-08	DRD1, DRD2, DRD3, DRD4, DRD5
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.298E-05	1.869E-04	DRD1, DRD2, DRD5
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	1.642E-03	3.489E-03	DRD1, DRD5
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	3.962E-04	1.347E-03	DRD1, DRD2
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	2.146E-10	3.649E-09	DRD1, DRD2, DRD3, DRD4, DRD5
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	1.225E-04	5.207E-04	DRD1, DRD2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05012	Parkinson's disease	1.027E-03	2.910E-03	DRD1, DRD2
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	1.624E-03	3.489E-03	DRD1, DRD2
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	3.108E-02	3.816E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	2.870E-02	3.816E-02	LMNA

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	DRD5;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1; DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;

Showing 1 to 10 of 21 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Stephania glabra

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities