Plant Name: Taxus mairei
Taxonomic Information:
Plant ID: NPO23720.1
Plant Latin Name: Taxus mairei
Taxonomy Genus: Taxus
Taxonomy Family: Taxaceae
Plant External Links:
NCBI TaxonomyDB:
120273
Plant-of-the-World-Online:
828365-1
Used in Medicines:
Unknown.
Geographical Distribution:
India; Taiwan; Nepal; China; Vietnam
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRD1; TACR2; | |
| MTOR; HSD17B10; USP2; | |
| MERTK; | |
| THRB; | |
| TP53; | |
| SLCO1B3; SLCO1B1; | |
| PMP22; GMNN; RAB9A; TUBB3; LMNA; NPC1; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Peptide receptor (family A GPCR) | TACR2 | Neurokinin 2 receptor | P21452 | CHEMBL2327 |
| Protein Kinase | MERTK | Proto-oncogene tyrosine-protein kinase MER | Q12866 | CHEMBL5331 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | TUBB3 | Tubulin beta-3 chain | Q13509 | CHEMBL2597 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0007610; behavior | GO:0007610; behavior | 4.831E-07 | 1.052E-02 | MTOR, NPC1, OPRD1, TACR2, THRB, TP53, USP2 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.888E-06 | 2.719E-02 | LMNA, MTOR, OPRD1, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.988E-05 | 2.832E-03 | SLCO1B1, SLCO1B3, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.811E-04 | 6.428E-03 | THRB, TP53, MTOR |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 1.716E-03 | 3.068E-02 | TP53, MTOR |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.822E-03 | 3.068E-02 | TP53, MTOR |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 2.161E-03 | 3.068E-02 | OPRD1, THRB, TACR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 3.187E-03 | 3.598E-02 | TP53, MTOR |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 3.548E-03 | 3.598E-02 | TP53, MTOR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 7.695E-03 | 5.463E-02 | LMNA, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 5.711E-03 | 5.068E-02 | OPRD1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 7.276E-03 | 5.463E-02 | RAB9A, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Solid tumors | NA | MTOR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MTOR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | THRB; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR; |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR; |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperthyroidism | E05 | THRB; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | High cholesterol levels in blood | E78.0 | THRB; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | THRB; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypothyroidism | E03 | THRB; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MTOR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Wound healing | T14.0-T14.1 | THRB; |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR; |
| NA: NA | Coronary artery restenosis | NA | MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
