| ICD10 Disease Category |
Disease Name |
ICD10 Code |
Linked Targets |
| G00-G99: Diseases of the nervous system G00-G99 |
Spinal muscular atrophy |
G00-G99 |
SMN1;SMN2 |
| C00-D49: Neoplasms |
Solid tumors |
NA |
MTOR |
| C00-D49: Neoplasms |
Solid tumours |
C00-D48 |
MTOR; TP53 |
| NA: NA |
Infantile colics |
NA |
TACR2 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism |
Transplant rejection |
D89.8, T86 |
MTOR |
| S00-T88: Injury, poisoning and certain other consequences of external causes |
Toxicity |
T36-T50, T51-T65 |
TP53 |
| H60-H95: Diseases of the ear and mastoid process |
Hearing disorder |
H90.5 |
TP53 |
| C00-D49: Neoplasms |
Late-stage solid tumors |
C00-C75, C7A, C7B, D10-D36, D3A |
TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Lipid metabolism disorder |
E75-E78 |
THRB |
| C00-D49: Neoplasms |
Lymphoma |
C81-C86 |
MTOR |
| C00-D49: Neoplasms |
Acute myeloid leukemia |
C92.0 |
TP53; TP53 |
| NA: NA |
Acute nonspecific diarrhea |
NA |
OPRD1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Acute or chronic pain |
R52, G89 |
TACR2 |
| K00-K95: Diseases of the digestive system |
Diarrhea-predominant IBS |
K58.0 |
OPRD1 |
| C00-D49: Neoplasms |
Inflammatory disease |
C11, C44, K75.9, M00-M25 |
MTOR |
| C00-D49: Neoplasms |
Non-small cell lung cancer |
C33-C34 |
MTOR |
| I00-I99: Diseases of the circulatory system |
Ischemic heart diseases |
I20-I25 |
OPRD1 |
| A00-B99: Certain infectious and parasitic diseases |
Irritable bowel syndrome with diarrhoea |
A09, J45, K58, K59.1 |
TACR2 |
| A00-B99: Certain infectious and parasitic diseases |
Irritable bowel syndrome |
A09, K58, K59.1 |
TACR2 |
| I00-I99: Diseases of the circulatory system |
Renal artery disease |
I70.1 |
TP53 |
| C00-D49: Neoplasms |
Renal cancer |
C64 |
MTOR |
| I00-I99: Diseases of the circulatory system |
Restenosis |
I51.89 |
MTOR |
| C00-D49: Neoplasms |
Advanced kidney cancer |
C64 |
MTOR |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Cough |
R05 |
OPRD1 |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Hyperthyroidism |
E05 |
THRB |
| C00-D49: Neoplasms |
Head and neck cancer |
C07-C14, C32-C33 |
TP53 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism |
Organ rejection |
D89.8, T86 |
MTOR |
| C00-D49: Neoplasms |
Oral cavity cancer |
C00-C08 |
TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Alcohol use disorders |
F10.2 |
OPRD1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Depression |
F30-F39 |
TACR2; TACR2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue |
Rheumatoid arthritis |
M05-M06 |
OPRD1 |
| E00-E89: Endocrine, nutritional and metabolic diseases |
High cholesterol levels in blood |
E78.0 |
THRB |
| G00-G99: Diseases of the nervous system G00-G99 |
Pain |
G64, G90.0, R52, G89 |
MTOR; OPRD1; TACR2 |
| C00-D49: Neoplasms |
Pancreatic cancer |
C25 |
MTOR |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Hyperlipidaemia |
E78 |
THRB |
| C00-D49: Neoplasms |
Hematological malignancies |
C81-C86 |
TP53 |
| C00-D49: Neoplasms |
Colorectal cancer |
C18-C21 |
TP53 |
| C00-D49: Neoplasms |
Overactive bladder disorder |
C67, N32.81 |
OPRD1 |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Hypothyroidism |
E03 |
THRB |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Anxiety disorder |
F32, F40-F42 |
CYP3A4; OPRD1; TACR2 |
| NA: NA |
Anxiety disorders |
NA |
TACR2 |
| NA: NA |
Chronic diarrhea associated with inflammatory bowel disease |
NA |
OPRD1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Moderate-to-severe pain |
R52, G89 |
OPRD1 |
| C00-D49: Neoplasms |
Multiple myeloma |
C90 |
MTOR; MTOR |
| J00-J99: Diseases of the respiratory system |
Chronic obstructive pulmonary disease |
J40-J44, J47 |
TACR2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Premature ejaculation |
F52.4 |
OPRD1 |
| K00-K95: Diseases of the digestive system |
Postoperative ileus |
K31.5, K56.0, K56.3, K56.7, P76.1 |
TACR2 |
| J00-J99: Diseases of the respiratory system |
Asthma |
J45 |
TACR2 |
| N00-N99: Diseases of the genitourinary system |
Bladder disease |
N30-N32 |
OPRD1 |
| C00-D49: Neoplasms |
Bladder cancer |
C67 |
MTOR |
| A00-B99: Certain infectious and parasitic diseases |
Fungal infections |
B35-B49 |
RAB9A |
| G00-G99: Diseases of the nervous system G00-G99 |
Acute migraine |
G43 |
OPRD1 |
| C00-D49: Neoplasms |
Cancer |
C00-C96 |
MTOR; TP53 |
| S00-T88: Injury, poisoning and certain other consequences of external causes |
Wound healing |
T14.0-T14.1 |
THRB |
| C00-D49: Neoplasms |
Sarcoma |
C81-C86 |
MTOR |
| C00-D49: Neoplasms |
Non-hodgkin's lymphoma |
C85 |
MTOR |
| NA: NA |
Coronary artery restenosis |
NA |
MTOR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Major depressive disorder |
F32, F33, M32 |
OPRD1 |
| A00-B99: Certain infectious and parasitic diseases |
Dutch elm disease |
B81-B83 |
MTOR |
| N00-N99: Diseases of the genitourinary system |
Urinary incontinence |
N39.3, N39.4, R32 |
OPRD1; TACR2; TACR2 |
| K00-K95: Diseases of the digestive system |
Ulcerative colitis |
K51 |
MTOR |
