CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	AMY1A;AMY1B;AMY1C; TDP1; P4HB; GFER; AKR1B1; POLB;
Lysine demethylase	KDM4E;
Serine protease	F10;
Aspartic protease	BACE1;
Transferase	FUT7;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Enzyme_unclassified	AMY1A;AMY1B;AMY1C	Salivary alpha-amylase	P04745	CHEMBL2478
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Serine protease	F10	Coagulation factor X	P00742	CHEMBL244
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0005975; carbohydrate metabolic process	5.393E-06	2.349E-02	AKR1B1, AMY1A, AMY1B, AMY1C, FUT7
BP	GO:0032501; multicellular organismal process	GO:0007586; digestion	1.158E-05	4.204E-02	AMY1A, AMY1B, AMY1C
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	1.831E-09	1.993E-05	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	1.831E-09	1.993E-05	AMY1A, AMY1B, AMY1C
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	6.941E-07	3.778E-03	AKR1B1, AMY1A, AMY1B, AMY1C, BACE1, F10, FUT7, GFER, KDM4E, P4HB, POLB, TDP1

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4.493E-06	3.595E-05	AMY1A, AMY1B, AMY1C
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.786E-02	3.423E-02	AKR1B1
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1.549E-02	3.423E-02	FUT7
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.139E-02	3.423E-02	AKR1B1
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1.845E-02	3.423E-02	FUT7
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.904E-02	3.423E-02	AKR1B1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.963E-02	3.423E-02	POLB
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	2.309E-06	3.595E-05	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	1.820E-05	9.709E-05	AMY1A, AMY1B, AMY1C
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.965E-04	1.986E-03	FUT7, AMY1A, AMY1B, AMY1C, AKR1B1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cancer	C64	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hematology	D50-D77	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hemophilia	D66-D68	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Blood coagulation disorders	D65-D68	F10;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	F10;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	F10;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	F10;
I00-I99: Diseases of the circulatory system	Thromboembolic disorders	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Coagulation	I80-I82	F10;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cynoglossum germanicum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities