Plant Name: Cynoglossum germanicum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004556; alpha-amylase activity | 1.831E-09 | 1.993E-05 | AMY1A, AMY1B, AMY1C |
| MF | Unclassified; | GO:0103025; alpha-amylase activity (releasing maltohexaose) | 1.831E-09 | 1.993E-05 | AMY1A, AMY1B, AMY1C |
| MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 6.941E-07 | 3.778E-03 | AKR1B1, AMY1A, AMY1B, AMY1C, BACE1, F10, FUT7, GFER, KDM4E, P4HB, POLB, TDP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 4.493E-06 | 3.595E-05 | AMY1A; AMY1B; AMY1C |
| hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 2.309E-06 | 3.595E-05 | AMY1A; AMY1B; AMY1C |
| hsa04970 | Salivary secretion_Homo sapiens_hsa04970 | 1.820E-05 | 9.709E-05 | AMY1A; AMY1B; AMY1C |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 4.965E-04 | 1.986E-03 | FUT7; AMY1A; AMY1B; AMY1C; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.786E-02 | 3.423E-02 | AKR1B1 |
| hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.549E-02 | 3.423E-02 | FUT7 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.139E-02 | 3.423E-02 | AKR1B1 |
| hsa00514 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.845E-02 | 3.423E-02 | FUT7 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.904E-02 | 3.423E-02 | AKR1B1 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 1.963E-02 | 3.423E-02 | POLB |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hematology | D50-D77 | F10 |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | F10 |
| I00-I99: Diseases of the circulatory system | Thromboembolic disorders | I80-I82 | F10 |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | F10 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hemophilia | D66-D68 | F10 |
| I00-I99: Diseases of the circulatory system | Coagulation | I80-I82 | F10 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1 |
| NA: NA | Haemophilia B | NA | F10 |
| I00-I99: Diseases of the circulatory system | Deep vein thrombosis | I80-I82, I80.2 | F10 |
| I00-I99: Diseases of the circulatory system | Venous thromboembolism | I80-I82 | F10 |
| I00-I99: Diseases of the circulatory system | Venous thrombosis | I80-I82 | F10 |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F10 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Blood coagulation disorders | D65-D68 | F10 |
| I00-I99: Diseases of the circulatory system | Deep venous clots | I80.2 | F10 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1 |
| I00-I99: Diseases of the circulatory system | Prophylaxis of deep vein thrombosis | I80-I82, I80.2 | F10 |
| NA: NA | Christmas disease | NA | F10 |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | F10 |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | F10 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | F10 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | F10 |
| C00-D49: Neoplasms | Renal cancer | C64 | F10 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1 |
| I00-I99: Diseases of the circulatory system | Acute coronary syndrome | I74 | F10 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |