CMAUP Plant Collective Molecular Activities

Plant Name: Ageratum conyzoides

Taxonomic Information:

Plant ID: NPO23234
Plant Latin Name: Ageratum conyzoides
Taxonomy Genus: Ageratum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 68299
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Ghana; Tanzania; Indonesia; India; Malaysia; Rwanda; China; Vietnam; Thailand; Kenya; Nigeria; Philippines

Traditional Medicine System:

Indian Folk; TCM; Ayurveda; Siddha

Medicinal Functions:

Antiinflammatory; Lithontripic; Skin; Styptic; Vulnerary

Geographical Distribution:

Ghana; Philippines; Indonesia; India; Malaysia; Rwanda; China; Vietnam; Thailand; Kenya; Nigeria; Tanzania

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GABBR1;
Enzyme_unclassified	BLM; UBE2N;
GABA-A receptor	GABRR1;
Plant homeodomain	KMT2A;
ATP-binding cassette	ABCB1; ABCG2;
SLC superfamily of solute carriers	SLC6A1; SLC6A11;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	UBE2N	Ubiquitin-conjugating enzyme E2 N	P61088	CHEMBL6089
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
SLC superfamily of solute carriers	SLC6A1	GABA transporter 1	P30531	CHEMBL1903
SLC superfamily of solute carriers	SLC6A11	GABA transporter 3	P48066	CHEMBL5208
Small molecule receptor (family C GPCR)	GABBR1	GABA-B receptor 1	Q9UBS5	CHEMBL2064
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005332; gamma-aminobutyric acid:sodium symporter activity	1.768E-06	3.207E-02	SLC6A1, SLC6A11
BP	GO:0051179; localization	GO:0015812; gamma-aminobutyric acid transport	8.240E-06	4.486E-02	SLC6A1, SLC6A11
MF	GO:0005215; transporter activity	GO:0008559; xenobiotic transmembrane transporting ATPase activity	6.182E-06	4.486E-02	ABCB1, ABCG2
BP	GO:0051179; localization	GO:0042908; xenobiotic transport	1.323E-05	4.803E-02	ABCB1, ABCG2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04727	GABAergic synapse	1.128E-07	2.594E-06	GABBR1, GABRR1, SLC6A11, SLC6A1
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	2.569E-04	2.954E-03	ABCB1, ABCG2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.694E-04	5.132E-03	ABCB1, ABCG2
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	1.097E-03	6.305E-03	GABBR1, GABRR1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.680E-03	4.453E-02	GABBR1, GABRR1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.717E-02	6.576E-02	CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00310	Lysine degradation	2.824E-02	6.576E-02	KMT2A
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	1.584E-02	6.072E-02	BLM
09120 Genetic Information Processing	09124 Replication and repair	hsa03460	Fanconi anemia pathway	2.877E-02	6.576E-02	BLM
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.145E-02	6.576E-02	CYP19A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1;
C00-D49: Neoplasms	Ovarian cancer	C56	ABCB1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	ABCB1;
C00-D49: Neoplasms	Cancer	C00-C96	ABCB1;
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases