Plant Name: Valeriana microphylla
Taxonomic Information:
Plant ID: NPO22892
Plant Latin Name: Valeriana microphylla
Taxonomy Genus: Valeriana
Taxonomy Family: Caprifoliaceae
Plant External Links:
NCBI TaxonomyDB:
243116
Plant-of-the-World-Online:
286639-2
Used in Medicines:
Unknown.
Geographical Distribution:
Peru; Ecuador; Colombia
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| DRD3; HTR2C; | |
| OPRD1; | |
| PTPN1; PTPN2; | |
| NR1H4; | |
| BACE1; | |
| VCP; | |
| MCL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Endoplasmic reticular retrotranslocon family | VCP | Transitional endoplasmic reticulum ATPase | P55072 | CHEMBL1075145 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Small molecule receptor (family A GPCR) | DRD3 | Dopamine D3 receptor | P35462 | CHEMBL234 |
| Small molecule receptor (family A GPCR) | HTR2C | Serotonin 2c (5-HT2c) receptor | P28335 | CHEMBL225 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.157E-06 | 6.765E-03 | PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.275E-06 | 6.765E-03 | NR1H4, PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:1902532; negative regulation of intracellular signal transduction | 1.553E-06 | 6.765E-03 | DRD3, MCL1, NR1H4, PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0071073; positive regulation of phospholipid biosynthetic process | 6.936E-06 | 2.157E-02 | HTR2C, NR1H4 |
| BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 8.667E-06 | 2.359E-02 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response | 1.501E-05 | 3.468E-02 | PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 2.933E-04 | 1.091E-01 | PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding | 9.317E-04 | 1.439E-01 | HTR2C |
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 2.637E-03 | 2.599E-01 | BACE1, DRD3, HTR2C, OPRD1 |
| CC | GO:0032991; macromolecular complex | GO:0097136; Bcl-2 family protein complex | 2.793E-03 | 2.599E-01 | MCL1 |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 2.793E-03 | 2.599E-01 | PTPN1 |
| CC | GO:0016020; membrane | GO:0016020; membrane | 3.979E-03 | 3.103E-01 | BACE1, DRD3, HTR2C, MCL1, OPRD1, PTPN1, PTPN2, VCP |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 2.075E-04 | 3.943E-03 | OPRD1, HTR2C, DRD3 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 2.153E-03 | 2.045E-02 | PTPN2, MCL1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.448E-02 | 8.733E-02 | VCP |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 3.282E-02 | 8.733E-02 | PTPN1 |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.325E-02 | 8.733E-02 | HTR2C |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.151E-02 | 8.733E-02 | NR1H4 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 3.892E-02 | 8.733E-02 | HTR2C |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 4.800E-02 | 8.733E-02 | PTPN1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 4.930E-02 | 8.733E-02 | HTR2C |
| 09150 Organismal Systems | 09156 Nervous system | hsa04728 | Dopaminergic synapse | 5.659E-02 | 8.733E-02 | DRD3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | OPRD1; |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | OPRD1; |
| K00-K95: Diseases of the digestive system | Diarrhea-predominant IBS | K58.0 | OPRD1; |
| NA: NA | Chronic diarrhea associated with inflammatory bowel disease | NA | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | OPRD1; |
| I00-I99: Diseases of the circulatory system | Ischemic heart diseases | I20-I25 | OPRD1; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | OPRD1; |
| N00-N99: Diseases of the genitourinary system | Bladder disease | N30-N32 | OPRD1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | OPRD1; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Moderate-to-severe pain | R52, G89 | OPRD1; |
| N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Premature ejaculation | F52.4 | OPRD1; |
| NA: NA | Acute nonspecific diarrhea | NA | OPRD1; |
| G00-G99: Diseases of the nervous system G00-G99 | Acute migraine | G43 | OPRD1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
