CMAUP Plant Collective Molecular Activities

Plant Name: Physostigma venenosum

Taxonomic Information:

Plant ID: NPO228
Plant Latin Name: Physostigma venenosum
Taxonomy Genus: Physostigma
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 271807
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Jordan; India

Traditional Medicine System:

Unani; TCM; Homeopathy

Geographical Distribution:

India; Jordan; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Peptide receptor (family A GPCR)	OPRD1;
Hydrolase	BCHE; ACHE;
Enzyme_unclassified	BLM; AMY1A;AMY1B;AMY1C; GFER;
Protein Phosphatase	PTPRS;
Protein Kinase	PIM1; KIT; GRK6;
Transcription Factor	TP53;
Unclassified	LMNA; NPC1; RAB9A;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	AMY1A;AMY1B;AMY1C	Salivary alpha-amylase	P04745	CHEMBL2478
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KIT	Stem cell growth factor receptor	P10721	CHEMBL1936
Protein Kinase	GRK6	G protein-coupled receptor kinase 6	P43250	CHEMBL6144
Protein Phosphatase	PTPRS	Receptor-type tyrosine-protein phosphatase S	Q13332	CHEMBL2396508
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	1.280E-08	1.394E-04	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	1.280E-08	1.394E-04	AMY1A, AMY1B, AMY1C
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.238E-06	6.741E-03	ACHE, BCHE
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.238E-06	9.745E-03	CYP1A1, CYP1B1, CYP2D6
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	7.754E-06	2.111E-02	BCHE, CYP1A1, CYP1B1, CYP2D6
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	9.765E-06	2.363E-02	BLM, CYP1A1, CYP1B1, KIT, NPC1, TP53
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.764E-05	3.841E-02	CYP1A1, CYP1B1, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.591E-05	4.031E-02	BCHE, CYP2D6
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	2.591E-05	4.031E-02	CYP1A1, CYP2D6
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	3.063E-05	4.447E-02	CYP1A1, CYP1B1, CYP2D6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3.083E-05	1.095E-03	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	1.591E-05	1.095E-03	AMY1A, AMY1B, AMY1C
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6.835E-05	1.618E-03	CYP2D6, CYP1A1, CYP1B1
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	1.234E-04	2.190E-03	AMY1A, AMY1B, AMY1C
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.784E-04	1.247E-02	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.370E-03	1.622E-02	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.777E-03	1.632E-02	KIT, PIM1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.446E-03	1.929E-02	KIT, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.839E-03	1.632E-02	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.637E-03	2.582E-02	CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases