CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	1.280E-08	1.394E-04	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	1.280E-08	1.394E-04	AMY1A, AMY1B, AMY1C
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.238E-06	6.741E-03	ACHE, BCHE
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.238E-06	9.745E-03	CYP1A1, CYP1B1, CYP2D6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00500	Starch and sucrose metabolism_Homo sapiens_hsa00500	3.083E-05	1.095E-03	AMY1A; AMY1B; AMY1C
hsa04973	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.591E-05	1.095E-03	AMY1A; AMY1B; AMY1C
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	6.835E-05	1.618E-03	CYP2D6; CYP1A1; CYP1B1
hsa04970	Salivary secretion_Homo sapiens_hsa04970	1.234E-04	2.190E-03	AMY1A; AMY1B; AMY1C
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	8.784E-04	1.247E-02	CYP1A1; CYP1B1
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.370E-03	1.622E-02	CYP1A1; CYP1B1
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	1.777E-03	1.632E-02	KIT; PIM1
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	2.446E-03	1.929E-02	KIT; TP53
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.839E-03	1.632E-02	CYP1A1; CYP1B1
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	4.050E-03	2.614E-02	PIM1; CYP1B1; TP53
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	3.637E-03	2.582E-02	CYP1A1; CYP1B1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	7.625E-03	4.511E-02	OPRD1; TP53

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1; ACHE
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; TP53; KIT; ACHE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ACHE; ACHE
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; KIT
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	KIT
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
NA: NA	Acute nonspecific diarrhea	NA	OPRD1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Physostigma venenosum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases