CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	CDC25B;
Enzyme_unclassified	BLM; TDP1; RECQL; ALOX15; HSD17B10; IDO1; BRCA1; APEX1;
Protein Kinase	MAPK1;
Lysine demethylase	KDM4E;
Cysteine protease	CASP7;
Transcription Factor	TP53;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	3.174E-08	6.910E-04	BLM, RECQL, TP53
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	3.015E-07	2.115E-03	APEX1, BLM, BRCA1, CASP7, MAPK1, TP53
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	1.705E-06	5.305E-03	APEX1, BLM, BRCA1, MAPK1, TP53
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	4.978E-06	1.286E-02	APEX1, BLM, BRCA1, CASP7, MAPK1
BP	GO:0009987; cellular process	GO:1902749; regulation of cell cycle G2/M phase transition	1.885E-05	1.786E-02	BLM, BRCA1, CDC25B, TP53
CC	GO:0043226; organelle	GO:0000800; lateral element	6.712E-05	3.654E-02	BLM, BRCA1
MF	GO:0005488; binding	GO:0003684; damaged DNA binding	1.753E-07	1.909E-03	APEX1, BLM, BRCA1, TP53
MF	GO:0003824; catalytic activity	GO:0009378; four-way junction helicase activity	5.621E-06	1.286E-02	BLM, RECQL
MF	GO:0003824; catalytic activity	GO:0043140; ATP-dependent 3'-5' DNA helicase activity	1.179E-05	1.677E-02	BLM, RECQL
MF	GO:0005488; binding	GO:0036310; annealing helicase activity	1.572E-05	1.677E-02	BLM, RECQL

Showing 1 to 10 of 11 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09124 Replication and repair	hsa03460	Fanconi anemia pathway	7.077E-04	9.300E-03	BLM, BRCA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	8.321E-04	9.300E-03	MAPK1, TP53, CDC25B
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.436E-04	6.886E-03	CASP7, MAPK1, TP53
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.266E-03	9.300E-03	SLCO1B1, SLCO1B3
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	5.717E-05	6.403E-03	MAPK1, BRCA1, TP53, CDC25B
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.459E-04	6.886E-03	CASP7, MAPK1, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.107E-04	6.886E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	4.233E-04	9.300E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	6.813E-04	9.300E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	7.898E-04	9.300E-03	MAPK1, TP53

Showing 1 to 10 of 17 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	IDO1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	IDO1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Speranskia tuberculata

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities