Plant Name: Speranskia tuberculata
Taxonomic Information:
Plant ID: NPO22578
Plant Latin Name: Speranskia tuberculata
Taxonomy Genus: Speranskia
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
1880644
Plant-of-the-World-Online:
356422-1
Used in Medicines:
Unknown.
Geographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CDC25B; | |
| BLM; TDP1; RECQL; ALOX15; HSD17B10; IDO1; BRCA1; APEX1; | |
| MAPK1; | |
| KDM4E; | |
| CASP7; | |
| TP53; | |
| SLCO1B3; SLCO1B1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | IDO1 | Indoleamine 2,3-dioxygenase | P14902 | CHEMBL4685 |
| Enzyme_unclassified | BRCA1 | Breast cancer type 1 susceptibility protein | P38398 | CHEMBL5990 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 3.174E-08 | 6.910E-04 | BLM, RECQL, TP53 |
| MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 1.753E-07 | 1.909E-03 | APEX1, BLM, BRCA1, TP53 |
| BP | GO:0050896; response to stimulus | GO:0071417; cellular response to organonitrogen compound | 3.015E-07 | 2.115E-03 | APEX1, BLM, BRCA1, CASP7, MAPK1, TP53 |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 1.705E-06 | 5.305E-03 | APEX1, BLM, BRCA1, MAPK1, TP53 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 4.978E-06 | 1.286E-02 | APEX1, BLM, BRCA1, CASP7, MAPK1 |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 5.621E-06 | 1.286E-02 | BLM, RECQL |
| MF | GO:0003824; catalytic activity | GO:0043140; ATP-dependent 3'-5' DNA helicase activity | 1.179E-05 | 1.677E-02 | BLM, RECQL |
| MF | GO:0005488; binding | GO:0036310; annealing helicase activity | 1.572E-05 | 1.677E-02 | BLM, RECQL |
| BP | GO:0009987; cellular process | GO:1902749; regulation of cell cycle G2/M phase transition | 1.885E-05 | 1.786E-02 | BLM, BRCA1, CDC25B, TP53 |
| MF | GO:0003824; catalytic activity | GO:0051213; dioxygenase activity | 4.274E-05 | 2.915E-02 | ALOX15, IDO1, KDM4E |
| CC | GO:0043226; organelle | GO:0000800; lateral element | 6.712E-05 | 3.654E-02 | BLM, BRCA1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 5.717E-05 | 6.403E-03 | MAPK1, BRCA1, TP53, CDC25B |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.436E-04 | 6.886E-03 | CASP7, MAPK1, TP53 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.459E-04 | 6.886E-03 | CASP7, MAPK1, HSD17B10 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 2.107E-04 | 6.886E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 4.233E-04 | 9.300E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 6.813E-04 | 9.300E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 7.898E-04 | 9.300E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 8.321E-04 | 9.300E-03 | MAPK1, TP53, CDC25B |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 1.063E-03 | 9.300E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 9.673E-04 | 9.300E-03 | MAPK1, TP53 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03460 | Fanconi anemia pathway | 7.077E-04 | 9.300E-03 | BLM, BRCA1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.095E-03 | 9.300E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.129E-03 | 9.300E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 1.266E-03 | 9.300E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.338E-03 | 9.300E-03 | MAPK1, TP53 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.266E-03 | 9.300E-03 | SLCO1B1, SLCO1B3 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 1.412E-03 | 9.300E-03 | CASP7, MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
