Plant Name: Speranskia tuberculata
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 3.174E-08 | 6.910E-04 | BLM, RECQL, TP53 |
| MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 1.753E-07 | 1.909E-03 | APEX1, BLM, BRCA1, TP53 |
| BP | GO:0050896; response to stimulus | GO:0071417; cellular response to organonitrogen compound | 3.015E-07 | 2.115E-03 | APEX1, BLM, BRCA1, CASP7, MAPK1, TP53 |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 1.705E-06 | 5.305E-03 | APEX1, BLM, BRCA1, MAPK1, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 5.717E-05 | 6.403E-03 | MAPK1; BRCA1; TP53; CDC25B |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 1.436E-04 | 6.886E-03 | CASP7; MAPK1; TP53 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 2.459E-04 | 6.886E-03 | CASP7; MAPK1; HSD17B10 |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 2.107E-04 | 6.886E-03 | MAPK1; TP53 |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 4.233E-04 | 9.300E-03 | MAPK1; TP53 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 6.813E-04 | 9.300E-03 | MAPK1; TP53 |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 7.898E-04 | 9.300E-03 | MAPK1; TP53 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 8.321E-04 | 9.300E-03 | MAPK1; TP53; CDC25B |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 1.063E-03 | 9.300E-03 | MAPK1; TP53 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 9.673E-04 | 9.300E-03 | MAPK1; TP53 |
| hsa03460 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 7.077E-04 | 9.300E-03 | BLM; BRCA1 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.095E-03 | 9.300E-03 | MAPK1; TP53 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.920E-03 | 1.167E-02 | MAPK1; BRCA1; TP53 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.129E-03 | 9.300E-03 | MAPK1; TP53 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 1.266E-03 | 9.300E-03 | MAPK1; TP53 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.338E-03 | 9.300E-03 | MAPK1; TP53 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.980E-03 | 1.167E-02 | MAPK1; TP53 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.266E-03 | 9.300E-03 | SLCO1B1; SLCO1B3 |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 2.394E-03 | 1.341E-02 | MAPK1; CDC25B |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 1.412E-03 | 9.300E-03 | CASP7; MAPK1 |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 3.004E-03 | 1.584E-02 | CASP7; MAPK1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 3.112E-03 | 1.584E-02 | ALOX15; MAPK1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 3.447E-03 | 1.596E-02 | MAPK1; TP53 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 3.562E-03 | 1.596E-02 | MAPK1; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 5.222E-03 | 2.089E-02 | MAPK1; TP53 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 3.562E-03 | 1.596E-02 | MAPK1; TP53 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 4.355E-03 | 1.806E-02 | MAPK1; TP53 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 3.798E-03 | 1.636E-02 | TP53; CDC25B |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 9.868E-03 | 3.754E-02 | MAPK1; TP53 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.006E-02 | 3.754E-02 | MAPK1; TP53 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Ocular cancer | C69 | APEX1 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | IDO1 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; IDO1; MAPK1; TP53 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MAPK1; TP53 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |