CMAUP Plant Collective Molecular Activities

Plant Name: Hylomecon japonica

Taxonomic Information:

Plant ID: NPO22043
Plant Latin Name: Hylomecon japonica
Taxonomy Genus: Hylomecon
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 72187
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	MTOR;
Transcription Factor	TP53;
SLC superfamily of solute carriers	SLC10A1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	THPO; LMNA; RAD52;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLC10A1	Bile acid transporter	Q14973	CHEMBL5287
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAD52	DNA repair protein RAD52 homolog	P43351	CHEMBL2362978

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.745E-09	5.978E-05	CYP1A2, CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.924E-06	2.095E-02	CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	6.182E-06	3.365E-02	CYP1A2, CYP2D6
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.940E-05	3.382E-02	CYP1A2, CYP2C19
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	2.425E-05	3.382E-02	LMNA, MTOR, TP53
MF	GO:0003824; catalytic activity	GO:0004497; monooxygenase activity	1.848E-05	3.382E-02	CYP1A2, CYP2C19, CYP2D6
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.940E-05	3.382E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.292E-05	3.382E-02	SMN1, SMN2
MF	GO:0005488; binding	GO:0020037; heme binding	4.511E-05	4.093E-02	CYP1A2, CYP2C19, CYP2D6
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	4.489E-05	4.093E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.357E-06	4.323E-04	CYP2D6, CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	5.613E-04	9.622E-03	TP53, MTOR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.108E-04	3.766E-03	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	5.963E-04	9.622E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.049E-03	9.940E-03	TP53, MTOR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.075E-04	9.622E-03	CYP2D6, CYP1A2
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.169E-03	9.940E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.917E-04	9.940E-03	CYP1A2, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.654E-03	1.247E-02	CYP2D6, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.833E-03	1.247E-02	TP53, MTOR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases