Plant Name: Hylomecon japonica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.745E-09 | 5.978E-05 | CYP1A2, CYP2C19, CYP2D6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 6.357E-06 | 4.323E-04 | CYP2D6; CYP1A2; CYP2C19 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 5.613E-04 | 9.622E-03 | TP53; MTOR |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.108E-04 | 3.766E-03 | CYP1A2; CYP2C19 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 5.963E-04 | 9.622E-03 | TP53; MTOR |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 1.049E-03 | 9.940E-03 | TP53; MTOR |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 7.075E-04 | 9.622E-03 | CYP2D6; CYP1A2 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.169E-03 | 9.940E-03 | TP53; MTOR |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 8.917E-04 | 9.940E-03 | CYP1A2; CYP2C19 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.654E-03 | 1.247E-02 | CYP2D6; CYP2C19 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.833E-03 | 1.247E-02 | TP53; MTOR |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 2.567E-03 | 1.557E-02 | LMNA; TP53 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 3.255E-03 | 1.703E-02 | THPO; MTOR |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 5.309E-03 | 2.407E-02 | TP53; MTOR |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 3.843E-03 | 1.867E-02 | SMN2; SMN1 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.106E-02 | 4.702E-02 | TP53; MTOR |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.747E-03 | 1.557E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| NA: NA | Coronary artery restenosis | NA | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MTOR; TP53 |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; MTOR |
| C00-D49: Neoplasms | Cancer | C00-C96 | MTOR; TP53 |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR |