CMAUP Plant Collective Molecular Activities

Plant Name: Ephedra intermedia

Taxonomic Information:

Plant ID: NPO21507
Plant Latin Name: Ephedra intermedia
Taxonomy Genus: Ephedra
Taxonomy Family: Ephedraceae

Plant External Links:

NCBI TaxonomyDB: 173278
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India; China

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Antiasthmatic; Antidote; Antihydrotic; Diaphoretic; Diuretic; Vasoconstrictor; Vasodilator

Geographical Distribution:

India; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NMUR2;
Small molecule receptor (family A GPCR)	ADRA2A;
Enzyme_unclassified	CES1; TDP1; BLM; PKM; ALOX12; CBR1; HSD17B10; ALOX15; APEX1; CES2;
Nicotinic acetylcholine receptor	CHRNA3; CHRNA4;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Oxidoreductase	ALOX5;
Serine protease	DPP4;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	HIF1A;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	CES2	Carboxylesterase 2	O00748	CHEMBL3180
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nicotinic acetylcholine receptor	CHRNA3	Neuronal acetylcholine receptor subunit alpha-3	P32297	CHEMBL3068
Nicotinic acetylcholine receptor	CHRNA4	Neuronal acetylcholine receptor protein alpha-4 subunit	P43681	CHEMBL1882
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Serine protease	DPP4	Dipeptidyl peptidase IV	P27487	CHEMBL284
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	7.468E-09	1.162E-05	CHRNA4, DPP4, HIF1A, LMNA, PKM, PPARA, PPARD, TLR2
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	7.656E-08	8.148E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.232E-08	8.148E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0007610; behavior	GO:0035095; behavioral response to nicotine	1.439E-07	1.306E-04	CHRNA3, CHRNA4, PPARA
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	1.891E-07	1.525E-04	ALOX12, ALOX15, ALOX5, TLR2
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.230E-07	1.734E-04	ALOX12, ALOX15, ALOX5, CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.917E-07	3.692E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	8.994E-07	6.120E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.162E-06	7.670E-04	CES1, CES2, CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	2.279E-06	1.341E-03	ALOX12, ALOX15, ALOX5
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	2.659E-06	1.379E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	2.659E-06	1.379E-03	ALOX12, ALOX15
BP	GO:0051179; localization	GO:0015908; fatty acid transport	4.418E-06	2.237E-03	FABP3, NMUR2, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.383E-06	2.548E-03	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	7.968E-06	3.470E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	7.968E-06	3.470E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	7.968E-06	3.470E-03	CES1, CES2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.592E-05	5.876E-03	CYP1A2, CYP2C9
BP	GO:0007610; behavior	GO:0007610; behavior	2.353E-05	8.133E-03	CHRNA3, CHRNA4, DPP4, HIF1A, NMUR2, PPARA, TLR2
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	2.651E-05	8.745E-03	ALOX12, ALOX15
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	1.736E-04	3.708E-02	ADRA2A, CHRNA3, CHRNA4, TLR2, TSHR
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.737E-04	3.708E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.050E-04	4.178E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.108E-04	2.990E-03	CYP2C9, ALOX15
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.994E-04	3.448E-03	CHRNA3, ADRA2A, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4.167E-04	3.448E-03	FABP4, TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.108E-04	3.448E-03	CYP2C9, ALOX15
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.654E-03	8.931E-03	CYP2C9, ALOX15

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases