CMAUP Plant Collective Molecular Activities

Plant Name: Ephedra intermedia

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	7.468E-09	1.162E-05	CHRNA4, DPP4, HIF1A, LMNA, PKM, PPARA, PPARD, TLR2
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	7.656E-08	8.148E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.232E-08	8.148E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0007610; behavior	GO:0035095; behavioral response to nicotine	1.439E-07	1.306E-04	CHRNA3, CHRNA4, PPARA
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	1.891E-07	1.525E-04	ALOX12, ALOX15, ALOX5, TLR2
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.230E-07	1.734E-04	ALOX12, ALOX15, ALOX5, CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.917E-07	3.692E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	8.994E-07	6.120E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.162E-06	7.670E-04	CES1, CES2, CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	2.279E-06	1.341E-03	ALOX12, ALOX15, ALOX5
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	2.659E-06	1.379E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	2.659E-06	1.379E-03	ALOX12, ALOX15
BP	GO:0051179; localization	GO:0015908; fatty acid transport	4.418E-06	2.237E-03	FABP3, NMUR2, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.383E-06	2.548E-03	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	7.968E-06	3.470E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	7.968E-06	3.470E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	7.968E-06	3.470E-03	CES1, CES2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.592E-05	5.876E-03	CYP1A2, CYP2C9
BP	GO:0007610; behavior	GO:0007610; behavior	2.353E-05	8.133E-03	CHRNA3, CHRNA4, DPP4, HIF1A, NMUR2, PPARA, TLR2
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	2.651E-05	8.745E-03	ALOX12, ALOX15

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	5.892E-10	4.275E-08	CYP2C9; CBR1; ALOX5; ALOX15; ALOX12; CYP2C19
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	1.140E-09	4.275E-08	FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.246E-07	3.115E-06	CYP2C9; CYP1A2; ALOX15; CYP2C19
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	8.985E-07	1.685E-05	CYP2C9; ALOX5; ALOX15; ALOX12; CYP2C19
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	1.474E-05	1.843E-04	CYP2C9; CBR1; PKM; ALOX5; CYP1A2; ALOX15; ALOX12; CYP2C19; HSD17B10; CES1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	8.647E-06	1.297E-04	CYP2C9; CBR1; CYP1A2; CYP2C19
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	7.287E-05	7.807E-04	CHRNA3; CHRNA4; NMUR2; ADRA2A; TSHR
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.814E-04	1.701E-03	CYP2C9; CYP1A2; CYP2C19
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.144E-04	1.787E-03	CYP2C9; CBR1; CYP1A2
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	3.619E-03	2.467E-02	FABP4; TSHR
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.457E-03	1.842E-02	CES2; CES1
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	5.139E-03	2.965E-02	PKM; HIF1A
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	4.844E-03	2.965E-02	CYP2C9; CYP1A2
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	7.975E-03	4.272E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	CHRNA4
C00-D49: Neoplasms	Hematological malignancies	C81-C86	DPP4
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5; ALOX5; CBR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	CHRNA4; CHRNA4; ADRA2A
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRNA4
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
C00-D49: Neoplasms	Ocular cancer	C69	APEX1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	CES1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRNA4
NA: NA	Aneurysm	NA	CHRNA4
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5
NA: NA	Anxiety disorders	NA	CHRNA4
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
C00-D49: Neoplasms	Melanoma	C43	TLR2
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	CES1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5; CES1; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRNA4; CHRNA4
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	CES1
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CES1
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5
I00-I99: Diseases of the circulatory system	Hypotension	I95	CHRNA4
E00-E89: Endocrine, nutritional and metabolic diseases	Hypoglycemia	E16.0-E16.2	DPP4
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD; DPP4
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Autism	F84.0	DPP4
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2; DPP4
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRNA4
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; TLR2; PKM
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Smoking cessation	F17.2	CHRNA4
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
NA: NA	Dyslipidemia	NA	PPARD
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	DPP4
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Bone marrow transplantation	D89.8, T86	DPP4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRNA4; CHRNA4
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRNA4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Tobacco dependence	F17	CHRNA4
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	DPP4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRNA4
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRNA4; ADRA2A; PKM
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	CES1; PPARD
NA: NA	Hypertensive emergencies	NA	CHRNA4

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases