Plant Name: Polygala sibirica
Taxonomic Information:
Plant ID: NPO21485
Plant Latin Name: Polygala sibirica
Taxonomy Genus: Polygala
Taxonomy Family: Polygalaceae
Plant External Links:
NCBI TaxonomyDB:
690825
Plant-of-the-World-Online:
692327-1
Used in Medicines:
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Analgesic; Diuretic; Expectorant; Haemolytic; Infertility; Kidney; Nervine; Sedative
Geographical Distribution:
Ukraine; Romania; Bangladesh; South Africa; India; China; Russia; Bulgaria
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; | |
| TSHR; | |
| FAAH; TERT; ALOX15; HPGD; | |
| ACHE; | |
| PPARD; PPARA; PPARG; | |
| HMGCR; | |
| TLR2; | |
| TP53; | |
| FABP3; FABP2; FABP4; LMNA; FABP5; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Oxidoreductase | HMGCR | HMG-CoA reductase | P04035 | CHEMBL402 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.286E-08 | 2.741E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 7.568E-07 | 5.682E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 1.327E-06 | 8.254E-04 | ALOX15, PPARA, PPARD, TP53 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.547E-06 | 9.359E-04 | FABP3, FFAR1, PPARG, TLR2 |
| BP | GO:0032502; developmental process | GO:0048856; anatomical structure development | 4.026E-06 | 1.868E-03 | ACHE, ALOX15, FABP5, HPGD, LMNA, PPARA, PPARD, PPARG, SMN1, SMN2, TLR2, TP53, TSHR |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 4.423E-06 | 1.891E-03 | LMNA, PPARD, TERT, TP53 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 6.598E-06 | 2.395E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.124E-05 | 3.596E-03 | PPARA, PPARG |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.397E-05 | 4.168E-03 | FABP3, PPARA, PPARG, TLR2 |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 1.684E-05 | 4.642E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 1.684E-05 | 4.642E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 1.684E-05 | 4.642E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 1.684E-05 | 4.642E-03 | FABP3, PPARG |
| BP | GO:0008283; cell proliferation | GO:0048662; negative regulation of smooth muscle cell proliferation | 1.856E-05 | 4.929E-03 | PPARD, PPARG, TP53 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.976E-05 | 5.122E-03 | PPARA, PPARD, PPARG |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 2.356E-05 | 5.898E-03 | PPARA, TP53 |
| MF | GO:0005488; binding | GO:0043621; protein self-association | 2.651E-05 | 6.481E-03 | ACHE, PPARG, TP53 |
| MF | GO:0005488; binding | GO:0046983; protein dimerization activity | 3.030E-05 | 7.173E-03 | ACHE, HMGCR, HPGD, PPARD, PPARG, TERT, TLR2, TP53 |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 3.462E-05 | 7.935E-03 | PPARA, PPARD, PPARG |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 7.381E-05 | 1.413E-02 | SMN1, SMN2 |
| CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 8.718E-05 | 1.609E-02 | SMN1, SMN2 |
| CC | GO:0044464; cell part | GO:0034719; SMN-Sm protein complex | 1.704E-04 | 2.474E-02 | SMN1, SMN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 4.760E-13 | 3.570E-11 | FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 4.191E-04 | 1.572E-02 | PPARG, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 8.462E-04 | 2.116E-02 | HPGD, PPARG, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.563E-03 | 2.930E-02 | FABP4, TSHR |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 4.330E-03 | 6.343E-02 | PPARG, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 7.916E-03 | 6.343E-02 | PPARG, TP53, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04152 | AMPK signaling pathway | 7.414E-03 | 6.343E-02 | PPARG, HMGCR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 9.364E-03 | 6.343E-02 | LMNA, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 8.485E-03 | 6.343E-02 | PPARA, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 8.857E-03 | 6.343E-02 | TP53, TLR2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
