CMAUP Plant Collective Molecular Activities

Plant Name: Polygala sibirica

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.286E-08	2.741E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	7.568E-07	5.682E-04	FABP3, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	1.327E-06	8.254E-04	ALOX15, PPARA, PPARD, TP53
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	1.547E-06	9.359E-04	FABP3, FFAR1, PPARG, TLR2
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	4.026E-06	1.868E-03	ACHE, ALOX15, FABP5, HPGD, LMNA, PPARA, PPARD, PPARG, SMN1, SMN2, TLR2, TP53, TSHR
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	4.423E-06	1.891E-03	LMNA, PPARD, TERT, TP53
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	6.598E-06	2.395E-03	FFAR4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.124E-05	3.596E-03	PPARA, PPARG
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	1.397E-05	4.168E-03	FABP3, PPARA, PPARG, TLR2
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	1.684E-05	4.642E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	1.684E-05	4.642E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.684E-05	4.642E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	1.684E-05	4.642E-03	FABP3, PPARG
BP	GO:0008283; cell proliferation	GO:0048662; negative regulation of smooth muscle cell proliferation	1.856E-05	4.929E-03	PPARD, PPARG, TP53
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.976E-05	5.122E-03	PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	2.356E-05	5.898E-03	PPARA, TP53
MF	GO:0005488; binding	GO:0043621; protein self-association	2.651E-05	6.481E-03	ACHE, PPARG, TP53
MF	GO:0005488; binding	GO:0046983; protein dimerization activity	3.030E-05	7.173E-03	ACHE, HMGCR, HPGD, PPARD, PPARG, TERT, TLR2, TP53
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	3.462E-05	7.935E-03	PPARA, PPARD, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	4.760E-13	3.570E-11	FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	4.191E-04	1.572E-02	PPARG; TP53
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	8.462E-04	2.116E-02	HPGD; PPARG; TP53
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.563E-03	2.930E-02	FABP4; TSHR

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; TLR2
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53; TERT
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
C00-D49: Neoplasms	Prostate cancer	C61	TERT; TLR2
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1; PPARG; PPARG; PPARD
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARG; PPARD
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
NA: NA	Upper abdominal bloating	NA	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	HMGCR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG
NA: NA	Hyperlipidemia	NA	HMGCR
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HMGCR; PPARD
K00-K95: Diseases of the digestive system	Chemotherapy or radiotherapy-induced mucositis	K12.3, R52, G89	HMGCR
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HMGCR; PPARD
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HMGCR
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	FAAH; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
A00-B99: Certain infectious and parasitic diseases	HBV infection	B16, B18.0, B18.1	HMGCR
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53; TERT
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	FAAH
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
C00-D49: Neoplasms	Breast cancer	C50	TERT
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Cancer	C00-C96	TP53; ACHE; TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARG; PPARD; PPARD
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HMGCR
NA: NA	Cardiovascular disease	NA	HMGCR
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HMGCR
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	HMGCR
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Liver cancer	C22	TERT
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	FAAH; ACHE
NA: NA	Dyslipidemia	NA	HMGCR; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	HMGCR; PPARD; PPARD
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
C00-D49: Neoplasms	Melanoma	C43	TERT; TLR2
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	HMGCR
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARG; PPARD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT; PPARG
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Elevated CRP	E78.0	HMGCR
C00-D49: Neoplasms	Ovarian cancer	C56	TERT
C00-D49: Neoplasms	Multiple myeloma	C90	TERT; HMGCR
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT; TLR2
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PPARG; PPARG; ACHE; ACHE; ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases