CMAUP Plant Collective Molecular Activities

Plant Name: Senecio retrorsus

Taxonomic Information:

Plant ID: NPO21175
Plant Latin Name: Senecio retrorsus
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 422357
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ADA;
Miscellaneous ion channel	BCL2;
Enzyme_unclassified	TERT;
Protein Kinase	MAPK1;
ATP-binding cassette	ABCG2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Hydrolase	ADA	Adenosine deaminase	P00813	CHEMBL1910
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	2.095E-05	1.084E-01	ADA, BCL2, MAPK1, TERT
BP	GO:0050896; response to stimulus	GO:0000302; response to reactive oxygen species	3.892E-05	1.084E-01	ADA, BCL2, MAPK1
CC	GO:0044464; cell part	GO:0032839; dendrite cytoplasm	4.482E-05	1.084E-01	ADA, MAPK1
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	2.289E-05	1.084E-01	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	4.124E-05	1.084E-01	SLCO1B1, SLCO1B3
BP	GO:0032502; developmental process	GO:0014031; mesenchymal cell development	5.643E-05	1.117E-01	BCL2, MAPK1
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	5.643E-05	1.117E-01	SLCO1B1, SLCO1B3
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	1.301E-04	1.142E-01	ABCG2, ADA, BCL2, MAPK1
BP	GO:0032502; developmental process	GO:0048538; thymus development	1.344E-04	1.142E-01	BCL2, MAPK1
BP	GO:0051179; localization	GO:0006869; lipid transport	1.389E-04	1.142E-01	ABCG2, SLCO1B1, SLCO1B3
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	3.274E-04	1.307E-01	ADA, MAPK1
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.486E-03	2.653E-01	SLCO1B1, SLCO1B3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.010E-08	1.060E-06	SLCO1B1, SLCO1B3, CYP3A4, ABCG2
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	2.616E-04	1.139E-02	BCL2, MAPK1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	5.388E-04	1.139E-02	BCL2, MAPK1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6.932E-04	1.139E-02	BCL2, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	8.363E-04	1.139E-02	BCL2, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	7.207E-04	1.139E-02	BCL2, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	9.443E-04	1.139E-02	BCL2, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	9.763E-04	1.139E-02	BCL2, MAPK1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.325E-03	1.294E-02	BCL2, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	9.763E-04	1.139E-02	BCL2, MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hairy cell leukemia	C91.4	ADA;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	ADA;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	ADA;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immunodeficiency	D84.9	ADA;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases