CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
C00-D49: Neoplasms	Melanoma	C43	TERT
C00-D49: Neoplasms	Hairy cell leukemia	C91.4	ADA
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
C00-D49: Neoplasms	Breast cancer	C50	BCL2; TERT
C00-D49: Neoplasms	Cancer	C00-C96	BCL2; BCL2; MAPK1
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2
C00-D49: Neoplasms	Liver cancer	C22	TERT
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT
C00-D49: Neoplasms	Hematological malignancies	C81-C86	ADA
C00-D49: Neoplasms	Ovarian cancer	C56	TERT
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	ADA
C00-D49: Neoplasms	Prostate cancer	C61	BCL2; TERT
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immunodeficiency	D84.9	ADA
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2; TERT
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2
C00-D49: Neoplasms	Tumors	C00-D48	TERT

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Senecio retrorsus

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases